茶叶科学 ›› 2004, Vol. 24 ›› Issue (1): 1-11.doi: 10.13305/j.cnki.jts.2004.01.001
• • 下一篇
黄华涛1,许心青2
收稿日期:
2003-10-24
修回日期:
2004-02-11
出版日期:
2004-03-25
发布日期:
2019-09-11
作者简介:
Hervé Huang (1960— ), PhD, scientist at the International Agency for Research on Cancer, World Health Organization. His research interests and areas are genetics, molecular biology and pathology of brain, liver and prostate cancers, and tea and health. E-mail: huang@iarc.fr
Hervé Huang1, Xin-Qing Xu2
Received:
2003-10-24
Revised:
2004-02-11
Online:
2004-03-25
Published:
2019-09-11
摘要: 茶和茶叶组份抗癌活性的科学证据在体外细胞体系研究中业已确定,其分子作用机理正在被进一步阐明。这方面详细的文献综述近来已有报导。本文就最近几年动物试验,人体流行病学,人体干预研究以及临床实验方面的研究进展作一综述。
中图分类号:
黄华涛, 许心青. 茶抗癌活性的动物试验和人体研究新进展[J]. 茶叶科学, 2004, 24(1): 1-11. doi: 10.13305/j.cnki.jts.2004.01.001.
Hervé Huang, Xin-Qing Xu. Anticancer Activity of Tea: Evidence from Recent Animal Experiments and Human Studies[J]. Journal of Tea Science, 2004, 24(1): 1-11. doi: 10.13305/j.cnki.jts.2004.01.001.
[1] | Blumberg J.Introduction to the proceedings of the third International scientific symposium on tea and human health: Role of flavonoids in the diet[J]. J Nutr 2003, 133: 3244s-46s. |
[2] | Yang CS, Jee Y, Chung JY, et al. Tea and Tea Polyphenols in Cancer Prevention[J]. J Nutr 2000, 130: 472S-478S. |
[3] | Yang CS, Landau JM.Effects of tea consumption on nutrition and Health[J]. J Nutr 2000, 130: 2409-2412. |
[4] | McKay D L, Blumberg J B. The role of tea in human health: an update[J]. J Am. Coll. Nutr 2002, 21: 1-13. |
[5] | Yang CS Maliakal P, Meng X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol[J]. 2002, 42:25-54. |
[6] | Lambert JD, Yang CS.Mechanisms of cancer prevention by tea constituents[J]. J Nutr 2003, 133(10): 3262S-3267S. |
[7] | Arab L. Il’yasova D.The Epidemiology of Tea Consumption and Colorectal Cancer Incidence[J]. J Nutr 2003, 133: 3310S-3318S. |
[8] | IARC working group. IARC Monographs on the evaluation of the carcinogenic risk to humans: coffee, tea, mate, methylxantines and methylglyoxal (Vol 51)[M]. Lyon1991. pp l-513. |
[9] | Kamath AB, Wang L, Das H, et al. Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses[J]. Proc Natl Acad Sci U S A. 2003, 100(10): 6009-14 |
[10] | Chang LK, Wei TT, Chiu YF, et al. Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate[J]. Biochem Biophys Res Commun. 2003, 301(4):1062-8. |
[11] | Chen ZM. [Biochemical and molecular biological basis of the anticarcinogenic activity of tea polyphenolic compounds] [J] [in Chinese].2003, J of Tea Sci, 23(2): 83-93. |
[12] | Park AM, Dong Z.Signal transduction pathways: targets for green and black tea polyphenols[J]. J Biochem Mol Biol. 2003, 36(1):66-77. |
[13] | Ioannides C, Yoxall V.Antimutagenic activity of tea: role of polyphenols[J]. Curr Opin Clin Nutr Metab Care. 2003, 6(6):649-56. |
[14] | Higdon JV, Frei B.Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions[J]. Crit Rev Food Sci Nutr 2003, 43(1):89-143. |
[15] | Kazi A, Smith DM, Daniel K, et al. Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention [J]. In vivo. Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention [J]. In vivo.2002 Nov-Dec, 16(6):397-403. |
[16] | Lu YP, Lou YR, Xie JG, et al.Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumours in mice[J]. Proc Natl Acad Sci U S A. 2002, 99(19):12455-60 |
[17] | Conney AH, Lu YP, Lou YR, et al. Inhibitory effects of tea Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat [J]. Eur J Cancer Prev.2002, Suppl 2:S28-36. |
[18] | Liang YC, Tsai DC, Lin-Shiau SY, et al. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3, 3'-digallate in mouse[J]. Nutr Cancer. 2002, 42(2):217-23. |
[19] | Ohishi T, Kishimoto Y, Miura N, et al. Synergistic effects of (-)-epigallocatechin gallate with sulindac against colon carcinogenesis of rats treated with azoxymethane[J]. Cancer Lett. 2002, 177(1):49-56. |
[20] | Orner GA, Dashwood WM, Blum CA, et al. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac[J]. Carcinogenesis. 2003, 24(2):263-7. |
[21] | Orner GA, Dashwood WM, Blum CA, et al. Response of Apc Response of Apc(min) andA33 (delta N beta-cat) mutant mice to treatment with tea, sulindac,2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) [J]. Mutat Res.2002, 506-507:121-7. |
[22] | Huang H, Ushijima T, Nagao M, et al. Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice[J]. Cancer Lett. 2003, 198(1): 29-35. |
[23] | Huang H, Mahler-Araujo BM, Sankila A, et al. APC mutations in sporadic medulloblastomas[J]. Am J Pathol. 2000, 156(2): 433-7. |
[24] | Chhabra SK, Yang CS.Tea and prostate cancer[J]. Epidemiol Rev. 2001, 23(1):106-9. |
[25] | Gupta S, Mukhtar H.Green tea and prostate cancer[J]. Urol Clin North Am. 2002, 29(1): 49-57. |
[26] | Gupta S, Hastak K, Ahmad N, et al. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols[J]. Proc Natl Acad Sci U S A. 2001, 98(18):10350-5. |
[27] | Adhami VM, Ahmad N, Mukhtar H.Molecular targets for green tea in prostate cancer prevention[J]. J Nutr 2003, 133(7):2417S-24S. |
[28] | Zhou JR, Yu L, Zhong Y, et al. Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice[J]. J Nutr 2003, 133(2):516-21. |
[29] | Li N, Chen X, Liao J, et al. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin[J]. Carcinogenesis. 2002, 23(8):1307-13. |
[30] | Li ZG, Shimada Y, Sato F, et al.Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats[J]. Int J Oncol. 2002, 21(6):1275-83. |
[31] | Li ZG, Shimada Y, Sato F, et al. Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats[J]. Oncol Rep. 2003,10(2):421-6. |
[32] | Feng GK, Xie BF, Liu ZC, et al. [Tea polyphenol inhibit on growth of human nasopharyngeal carcinoma cell and xenograft in nude mice][J]. [in Chinese]. Ai Zheng. 2002, 21(4):392-4. |
[33] | Shukla Y, Taneja P.Anticarcinogenic effect of black tea on pulmonary tumors in Swiss albino mice[J]. Cancer Lett. 2002,176(2):137-41. |
[34] | Yanaga H, Fujii T, Koga T, et al. Prevention of carcinogenesis of mouse mammary epithelial cells RIII/MG by epigallocatechin gallate[J]. Int J Mol Med. 2002,10(3):311-5. |
[35] | Zhou JR, Yu L, Mai Z, et al. Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice[J]. Int J Cancer. 2004, 108(1):8-14 |
[36] | Umemura T, Kai S, Hasegawa R, et al. Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by green tea infusion[J]. Carcinogenesis. 2003, 24(6):1105-9. |
[37] | Sato D, Matsushima M.Preventive effects of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rat by green tea leaves[J]. Int J Urol. 2003, 10(3):160-6. |
[38] | Kemberling JK, Hampton JA, Keck RW, et al.Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate[J]. J Urol. 2003,170(3):773-6. |
[39] | Luceri C, Caderni G, Sanna A, et al. Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced f344 rat colon tumors[J]. J Nutr 2002,132(6):1376-9. |
[40] | Jia X, Han C, Chen J.Effects of tea on preneoplastic lesions and cell cycle regulators in rat liver[J]. Cancer Epidemiol Biomarkers Prev. 2002, 11(12):1663-7. |
[41] | Yang CS, Prabhu S, Landau J.Prevention of carcinogenesis by tea polyphenols[J]. Drug Metab Rev. 2001, 33(3-4):237-53. |
[42] | Bushman JL.Green tea and cancer in humans: a review of the literature[J]. Nutr Cancer. 1998, 31(3):151-9. |
[43] | Kohlmeier L, Weterings KG, Steck S, et al. Tea and cancer prevention: an evaluation of the epidemiologic literature[J]. Nutr Cancer. 1997, 27(1):1-13. |
[44] | Yang CS, Wang ZY.Tea and cancer[J]. J Natl Cancer Inst. 1993, 85(13):1038-49. |
[45] | Mu LN, Zhou XF, Ding BG, et al. Study on the protective effect of green tea on gastric, liver and esophageal cancers[J].[in Chinese] Zhonghua Yu Fang Yi Xue Za Zhi. 2003, 37(3):171-3. |
[46] | Mu LN, Zhou XF, Ding BG, et al. [A case-control study on drinking green tea and decreasing risk of cancers in the alimentary canal among cigarette smokers and alcohol drinkers][J]. [in Chinese] Zhonghua Liu Xing Bing Xue Za Zhi. 2003, 24(3):192-5. |
[47] | Gao CM, Takezaki T, Wu JZ, et al. Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China[J]. Cancer Lett. 2002, 188(1-2):95-102. |
[48] | Setiawan VW, Zhang ZF, Yu GP, et al. Protective effect of green tea on the risks of chronic gastritis and stomach cancer[J]. Int J Cancer. 2001, 92(4):600-4. |
[49] | Sun CL, Yuan JM, Lee MJ, et al. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China[J]. Carcinogenesis. 2002, 23(9):1497-503. |
[50] | Arab L, Il'yasova D. The epidemiology of tea consumption and colorectal cancer incidence[J]. J Nutr 2003,133(10):3310S-8S. |
[51] | Il’yasova D, Arab L, Martinchik A, et al. Black tea consumption and risk of rectal cancer in Moscow population[J]. Ann Epidemiol. 2003, 13(6):405-11. |
[52] | Ke L, Yu P, Zhang ZX, et al. Congou tea drinking and oesophageal cancer in South China[J]. Br J Cancer. 2002, 86(3):346-7 |
[53] | Wu AH, Yu MC, Tseng CC, et al. Green tea and risk of breast cancer in Asian Americans[J]. Int J Cancer. 2003,106(4):574-9. |
[54] | Tao MH, Liu DK, Gao LF, et al. [Relationshiop between tea drinking [Relationshiop between tea drinking and breast cancer in Women] [J]. [in Chinese]. Zhong Liu, 2002.3: |
[55] | Zhong L, Goldberg MS, Gao YT, et al. A population-based case-control study of lung cancer and green tea consumption among women living in Shanghai, China[J]. Epidemiology. 2001, 12(6):695-700. |
[56] | Jian L, Xie LP, Lee AH, et al.Protective effect of green tea against prostate cancer: A case-control study in southeast China[J]. Int J Cancer. 2004, 108(1):130-5. |
[57] | Zeegers MP, Dorant E, Goldbohm RA, et al. Are coffee, tea, and total fluid consumption associated with bladder cancer risk? Results from the Netherlands Cohort Study[J]. Cancer Causes Control. 2001, 12(3):231-8. |
[58] | Hakim IA, Harris RB.Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin[J]. BMC Dermatol. 2001,1(1):3. |
[59] | Nakachi K, Eguchi H, Imai K.Can teatime increase one's lifetime?[J] Ageing Res Rev. 2003, 2(1):1-10. |
[60] | Lambert JD, Yang CS. Cancer chemopreventive activity and bioavailability of tea and tea polyphenols [J]. Mutat Res.2003, 523-524:201-8. |
[61] | Lu H, Meng X, Yang CS.Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by(-)-epigallocatechin gallate[J]. Drug Metab Dispos. 2003, 31(5):572-9. |
[62] | Lu H, Meng X, Li C, et al. Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. Drug Metab Dispos[J]. 2003, 31(4): 452-61. |
[63] | Lee MJ, Maliakal P, Chen L, et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability[J]. Cancer Epidemiol Biomarkers Prev. 2002, 11(10 Pt 1):1025-32. |
[64] | Rietveld A, Wiseman S.Antioxidant effects of tea: evidence from human clinical trials[J]. J Nutr 2003, 133(10):3285S-3292S. |
[65] | Wu AH, Tseng CC, Van Den Berg D, et al. Tea intake, COMT genotype, and breast cancer in Asian-American women[J]. Cancer Res. 2003, 63(21):7526-9. |
[66] | Loktionov A, Bingham SA, Vorster H, et al. Apolipoprotein E genotype modulates the effect of black tea drinking on blood lipids and blood coagulation factors: a pilot study[J]. Br J Nutr 1998, 79(2):133-9. |
[67] | Li N, Sun Z, Han C, et al. The chemopreventive effects of tea on human oral precancerous mucosa lesions[J]. Proc Soc Exp Biol Med. 1999, 220(4):218-24. |
[68] | Hakim IA, Harris RB, Brown S, et al. Effect of Increased Tea Consumption on Oxidative DNA Damage among Smokers: A Randomized Controlled Study[J]. J Nutr 133: 3303S-3309S, 2003. |
[69] | Jatoi A, Ellison N, Burch PA, et al. A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma[J]. Cancer. 2003, 97(6):1442-6. |
[70] | Linden KG, Carpenter PM, McLaren CE, et al. Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea.[J]. Recent Results Cancer Res. 2003, 163:165-71. |
[71] | Wang LD, Zhou Q, Feng CW, et al. Intervention Intervention and follow-up on human esophageal precancerous lesions in Henan, northern China, a high-incidence area for esophageal cancer [J]. Gan To Kagaku Ryoho.2002, Suppl 1:159-72. |
[72] | Pisters KM, Newman RA, Coldman B, et al. Phase I trial of oral green tea extract in adult patients with solid tumors[J]. J Clin Oncol. 2001, 19(6):1830-8. |
[73] | Fujiki H, Suganuma M, Imai K, et al. Green tea: cancer preventive beverage and/or drug[J]. Cancer Lett. 2002,188(1-2):9-13. |
[74] | Chow HH, Cai Y, Hakim IA, et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals[J]. Clin Cancer Res. 2003, 9(9):3312-9. |
[75] | Warden BA, Smith LS, Beecher GR, et al. Catechins are bioavailable in men and women drinking black tea throughout the day[J]. J Nutr 2001 131(6):1731-7. |
[76] | Yang CS, Chen L, Lee MJ, et al. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers[J]. Cancer Epidemiol Biomarkers Prev. 1998, 7(4):351-4. |
[1] | 王留彬, 黄丽蕴, 滕翠琴, 吴立赟, 成浩, 于翠平, 王丽鸳. 梧州茶树种质资源的遗传多样性及亲缘关系分析[J]. 茶叶科学, 2022, 42(5): 601-609. |
[2] | 高健健, 陈丹, 彭佳堃, 吴文亮, 蔡良绥, 蔡亚威, 田军, 万云龙, 孙威江, 黄艳, 王哲, 林智, 戴伟东. 基于代谢组学的云南白茶与福鼎白茶化学成分比较分析[J]. 茶叶科学, 2022, 42(5): 623-637. |
[3] | 周汉琛, 杨霁虹, 徐玉婕, 吴琼, 雷攀登. 香叶醇生物合成相关基因NUDX1的进化分析[J]. 茶叶科学, 2022, 42(5): 638-648. |
[4] | 陈琪予, 马建强, 陈杰丹, 陈亮. 利用图像特征分析茶树成熟叶表型的遗传多样性[J]. 茶叶科学, 2022, 42(5): 649-660. |
[5] | 李艳春, 汪航, 李兆伟, 叶菁, 王义祥. 几种改良措施对酸化茶园土壤理化性质和微生物群落结构的影响[J]. 茶叶科学, 2022, 42(5): 661-671. |
[6] | 孙悦, 吴俊, 韦朝领, 刘梦月, 高晨曦, 张灵枝, 曹士先, 余顺甜, 金珊, 孙威江. 抗小贯松村叶蝉和茶棍蓟马的茶树种质筛选及其抗性相关因素分析[J]. 茶叶科学, 2022, 42(5): 689-704. |
[7] | 陈宇宏, 高颖, 韩震, 尹军峰. 不同种质茶叶籽皂素含量及组成分析[J]. 茶叶科学, 2022, 42(5): 705-716. |
[8] | 陈慧, 杨丽玲, 陈金华, 黄建安, 龚雨顺, 李适. 控温渥堆对黑毛茶香气品质的影响[J]. 茶叶科学, 2022, 42(5): 717-730. |
[9] | 陈珂, 王苑竹, 杨晓颖, 张冬英, 朱强强. 壳聚糖复合β-乳球蛋白负载EGCG纳米粒的制备及其对糖尿病小鼠血糖的影响[J]. 茶叶科学, 2022, 42(5): 731-739. |
[10] | 李峥, 刘锭, 霍增辉, 陈富桥. 中国与RCEP成员国茶叶贸易竞争性与互补性分析[J]. 茶叶科学, 2022, 42(5): 740-752. |
[11] | 俞蓉欣, 郑芹芹, 陈红平, 张劲松, 张相春. 儿茶素生物医用纳米材料研究进展[J]. 茶叶科学, 2022, 42(4): 447-462. |
[12] | 王玉源, 刘任坚, 刘少群, 舒灿伟, 孙彬妹, 郑鹏. 茶树R2R3-MYB转录因子CsTT2表达分析及功能初步鉴定[J]. 茶叶科学, 2022, 42(4): 463-476. |
[13] | 李晶, 林彩容, 黄艳, 邓旭铭, 王艺清, 孙威江. 茶多酚对农杆菌介导的植物遗传转化体系的影响[J]. 茶叶科学, 2022, 42(4): 477-490. |
[14] | 赵东伟. 大叶茶(Camellia sinensis var. assamica)的命名、模式及自然分布[J]. 茶叶科学, 2022, 42(4): 491-499. |
[15] | 刘建军, 张金玉, 彭叶, 刘晓博, 杨云, 黄涛, 温贝贝, 李美凤. 不同光质摊青对夏秋茶树鲜叶挥发性物质及其绿茶品质影响研究[J]. 茶叶科学, 2022, 42(4): 500-514. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||
|