咖啡碱的生理功能及其作用机制

doi:10.13305/j.cnki.jts.2010.04.001

Abstract

CLC Number:

S571
Q74

WU Ming-yan, FAN Fang-yuan, LIANG Yue-rong, ZHENG Xin-qiang, LU Jian-liang. The Physiological Functions of Caffeine and Their Related Mechanisms[J]. Journal of Tea Science, 2010, 30(4): 235-242.

[1] Fredholm, BB.Connection between caffeine, adenosine receptors and dopamine. Coffee reduces the risk of Parkinson disease[J]. Lakartidningen, 2004, 101(34): 2552-2555.
[2] Paré W.The effect of caffeine and seconal on a visual discrimination task[J]. Journal of Comparative and Physiological Psychology, 1961, 54(5): 506-509.
[3] Smith A.Effects of caffeine on human behavior[J]. Food and Chemical Toxicology, 2002, 40(9): 1243-1255.
[4] Peeling P, Dawson B.Influence of caffeine ingestion on perceived mood states, concentration, and arousal levels during a 75-min university lecture[J]. Advances in Physiology Education, 2007, 31(4): 332-335.
[5] Brunyé TT, Mahoney CR, Lieberman HR, et al. Caffeine modulates attention network function[J]. Brain and Cognition, 2010, 72(2): 181-188.
[6] 易超然. 咖啡因的药理作用和应用[J]. 医学研究生学报, 2005, 18(3): 270-271.
[7] Egawa T, Hamada T, Kameda N, et al. Caffeine acutely activates 5′adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles[J]. Metabolism Clinical and Experimental, 2009, 58(11): 1609-1617.
[8] Bidel S, Hu G, Tuomilehto J.Coffee consumption and Type 2 Diabetes - An extensive review[J]. Central European Journal of Medicine, 2008, 3(1): 9-19.
[9] MacKenzie T, Comi R, Sluss P, et al. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial[J]. Metabolism Clinical and Experimental, 2007, 56(12): 1694-1698.
[10] Bairam A, Montandon G, Joseph V, et al. Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: The role of testosterone[J]. Respiratory Physiology & Neurobiology, 2009, 165(2-3): 261-265.
[11] Bhatt-Mehta V, Schumacher RE.Treatment of apnea of prematurity[J]. Drugs, 2003, 5(3): 195-210.
[12] Bode AM, Dong ZG.The enigmatic effects of caffeine in cell cycle and cancer[J]. Cancer Letters, 2007, 247(1): 26-39.
[13] Celik T, Iyisoy A, Amasyali B.The effects of coffee intake on coronary heart disease: Ongoing controversy [J/OL]. [2009-11-18] International Journal of Cardiology, 2009, doi:10.1016/j.ijcard.2008.12.112.
[14] Montes FR, Cabrera M, Delgadillo A, et al. The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries[J]. Vascular Pharmacology, 2009, 50(3-4): 132-136.
[15] Robertson D, Frolich JC, Carr RK, et al. Effects of caffeine on plasma renin activity, catecholamines and blood pressure[J]. New England Journal of Medicine, 1978, 22(6): 548-549.
[16] Heaney RP, Recker RR.Effects of nitrogen, phosphorus, and caffeine on calcium balance in women[J]. The Journal of Laboratory and Clinical Medicine, 1982, 99(1): 46-55.
[17] Tsuang YH, Sun JS, Chen LT, et al. Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis[J]. Journal of Orthopaedic Surgery and Research, 2006, 1(7): 1-7.
[18] Rapuri PB, Gallagher JC, Kinyamu HK, et al. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes[J]. American Journal of Clinical Nutrition, 2001, 74(5): 694-700.
[19] Hallstrom T, Wolk A, Glynn A, et al. Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women[J]. Osteoporosis International, 2006, 17(7): 1055-1064.
[20] Weng XP, Odouli R, Li DK.Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study[J]. Obstetric Anesthesia Digest, 2008, 28(4): 229-230.
[21] Grosso LM, Bracken MB.Caffeine metabolism, genetics, and perinatal outcomes: A review of exposure assessment considerations during pregnancy[J]. Annals of Epidemiology, 2005, 15(6): 460-466.
[22] Soellner DE, Grandys T, Nuñez JL.Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats[J]. Behavioural Brain Research, 2009, 205(1): 191-199.
[23] 邵碧霞. 咖啡因对大鼠工作记忆促进作用及其机制的研究[J]. 中国药学杂志, 2006, 41(7): 512-514.
[24] 周赛君, 何金彩, 王小同. 咖啡因对小鼠空间学习记忆能力及有关脑区记忆相关蛋白CREB表达的影响[J]. 中国临床神经科学, 2008, 16(2): 139-144.
[25] Costa MS, Botton PH, Mioranzza S, et al. Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tyrosine kinase receptor(TrkB) content in mice[J]. Neuroscience, 2008, 153(4): 1071-1078.
[26] Arendash G, Rezai-Zadeh K, Cao C, et al. Caffeine: evidence for protection against, and treatment for, alzheimer’s disease by direct suppression of disease pathogenesis[J]. Alzheimer's and Dementia, 2007, 3(3): S166.
[27] Arendash GW, Schleif W, Rezai-Zadeh K, et al. Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain beta-amyloid production[J]. Neuroscience, 2006, 142(4): 941-952.
[28] Singh S, Singh K, Patel S, et al. Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype in mouse[J]. Brain Research, 2008(1207): 193-206.
[29] Ritchie K, Carrière I, de Mendonca A, et al. The neuroprotective effects of caffeine: a prospective population study (the Three City Study)[J]. Neurology, 2007, 69(6): 536-545.
[30] Luszczki JJ, Zuchora M, Sawicka KM, et al. Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice[J]. Pharmacological Reports, 2006, 58(5): 652-659.
[31] Singh S, Singh K, Gupta SP, et al. Effect of caffeine on the expression of cytochrome P450 1A2,adenosine A_2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum[J]. Brain Research, 2009(1283): 115-126.
[32] Mao X, Chai Y, Lin YF.Dual regulation of the ATP-sensitive potassium channel by caffeine[J]. American Journal of Physiology-Cell Physiology, 2007, 292(6): 2239-2258.
[33] Pleger B, Ruff CC, Blankenburg F, et al. Influence of dopaminergically mediated reward on somatosensory decision-
1)making[J]. PLoS Biology, 2009, doi:10.1371/journal.pbio.1000164.
[34] Avshalumov MV, Chen BT, Koos T, et al. Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels[J]. Journal of Neuroscience, 2005, 25(17): 4222-4231.
[35] Jones G.Caffeine and other sympathomimetic stimulants: modes of action and effects on sports performance[J]. Essays in biochemistry, 2008(44): 109-123.
[36] Rossi S, De Chiara V, Musella A, et al. Caffeine drinking potentiates cannabinoid transmission in the striatum: Interaction with stress effects[J]. Neuropharmacology, 2009, 56(3): 590-597.
[37] Lage R, Diégueza C, López M.Caffeine treatment regulates neuropeptide S system expression in the rat brain[J]. Neuroscience Letters, 2006, 410(1): 47-51.
[38] Chen XS, Lan X, Roche I, et al. caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum[J]. Journal of Neurochemistry, 2008, 107(4): 1147-1157.
[39] Nakaso K, Ito S, Nakashima K.Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson’s disease model of SH-SY5Y cells[J]. Neuroscience Letters, 2008, 432(2): 146-150.
[40] Huang YW, Liu Y, Dushenkov S.Anti-obesity effects of epigallocatechin-3-gallate, orange peel extract, black tea extract, caffeine and their combinations in a mouse model[J]. Journal of Functional Foods, 2009, 1(3): 304-310.
[41] 易超然, 卫中庆, 邓湘蕾. 咖啡因改善糖尿病大鼠膀胱功能的观察[J]. 中国糖尿病杂志, 2006, 14(2): 144-145.
[42] Van Dam RM.Coffee and type 2 diabetes: From beans to beta-cells[J]. Nutrition, Metabolism and Cardiovascular Diseases, 2006, 16(1): 69-77.
[43] Van Dam RM, Hu FB.Coffee consumption and risk of type 2 diabetes: a systematic review[J]. The Journal of the American Medical Association, 2005, 294(1): 97-104.
[44] Bairam A, Joseph V, Lajeunesse Y, et al. Altered expression of adenosine A1 and A2A receptors in the carotid body and nucleus tractus solitarius of adult male and female rats following neonatal caffeine treatment[J]. Brain Research, 2009(1287): 74-83.
[45] Schmidt B, Roberts RS, Davis P, et al. Caffeine Therapy for apnea of prematurity[J]. The New England Journal of Medicine, 2006, 354(20): 2112-2121.
[46] Schmidt B, Roberts RS, Davis P, et al. Long-term effects of caffeine therapy for apnea of prematurity[J]. The New England Journal of Medicine, 2007, 357(19): 1893-1902.
[47] Guillet R, Kellogg C.Neonatal exposure to therapeutic caffeine alters the ontogeny of adenosine A1 receptors in brain of rats[J]. Neuropharmacology, 1991, 30(5): 489-496.
[48] Desfrere L, Olivier P, Schwendimann L, et al. Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure[J]. Pediatric Research, 2007, 62(5): 604-609.
[49] Hunter DJ, Manson JE, Stampfer MJ, et al. A prospective study of caffeine, coffee, tea, and breast cancer[J]. American Journal of Epidemiology, 1992(136): 1000-1001.
[50] Vandrer A, Sherman J, Luciano D.Human physiology: The mechanisms of body function[M]. New York: McGraw-Hill, 1994.
[51] Merighis S, Benini A, Mirandola P, et al. Caffeine inhibits adenosine-induced accumulation of hypoxiainducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells[J]. Molecular pharmacology, 2007, 72(2): 395-406.
[52] 李文萍, 王颀, 许娟. 咖啡因对乳腺癌化疗增效作用的体外实验研究[J]. 肿瘤防治杂志, 2005, 12(24): 1857-1860.
[53] 陈剑, 顾传龙, 万双林. 咖啡因对Fischer 344/N大鼠骨肉瘤化疗的增效作用[J]. 浙江大学学报: 医学版, 2005, 34(5): 390-394.
[54] 崔秋, 李鼎锋, 尉承泽, 等. 咖啡因咖啡碱在骨肉瘤细胞株顺铂化疗中增效作用的实验研究[J]. 解放军医学杂志, 2008, 33(5): 582-584.
[55] Jha MN, Bamburg JR, Bernstein BW, et al. Caffeine eliminates gamma-ray-induced g2-phase delay in human tumor cells but not in normal cells[J]. Radiation Research, 2002, 157(1): 26-31.
[56] Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health[J]. Food Additives and Contaminants, 2003, 20(1): 1-30.
[57] Winkelmayer WC, Stampfer MJ, Willett WC, et al. Habitual caffeine intake and the risk of hypertension in women[J]. Division of Pharmacoepidemiology and Pharmacoeconomics, 2005, 294(18): 2330-2335.
[58] Ahmed HN, Levitan EB, Wolk A, et al. Coffee consumption and risk of heart failure in men: An analysis from the Cohort of Swedish Men[J]. American Heart Journal, 2009, 158(4):667-672.
[59] Umemura T, Ueda K, Nishioka K, et al. Effects of acute administration of caffeine on vascular function[J]. The American Journal of Cardiology, 2006, 98(11): 1538-1541.
[60] Ilbäck NG, Siller M, Stålhandske T, et al. Evaluation of cardiovascular effects of caffeine using telemetric monitoring in the conscious rat[J]. Food and Chemical Toxicology, 2007, 45(5): 834-842.
[61] Kennedy MD, Galloway AV, Dickau LJ, et al. The cumulative effect of coffee and a mental stress task on heart rate, blood pressure, and mental alertness is similar in caffeine-naive and caffeine-habituated females[J]. Nutrition Research, 2008, 28(9): 609-614.
[62] Hartley TR, Lovallo WR, Whitsett TL.Cardiovascular effects of caffeine in men and women[J]. The American journal of cardiology, 2004, 93(8): 1022-1026.
[63] Duarte PM, Marques MR, Bezerra JP, et al. The effects of caffeine administration on the early stage of bone healing and bone density[J]. Archives of Oral Biology, 2009, 54(8): 717-722.
[64] 潘晓靓, 刘冬琳, 孟巍. 咖啡因暴露对小鼠胚胎发育的影响[J]. 武汉大学学报: 医学版, 2008, 29(2): 165-168.
[65] Chen YH, Huang YH, Wen CC, et al. Movement disorder and neuromuscular change in zebrafish embryos after exposure to caffeine[J]. Neurotoxicology and Teratology, 2008, 30(5): 440-447.
[66] Nomura K, Saito S, Ide K.Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell culture and rat placenta[J]. Journal of Nutritional Biochemistry, 2004, 15(6): 342-349.
[67] Miao YL, Shi LH, Lei ZL.Effects of caffeine on in vivo and in vitro oocyte maturation in mice[J]. Theriogenology, 2007, 68(4): 640-645.
[68] Picard N, Guénin S, Larnicol N, et al. Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A_2A and GABAA receptor mRNA transcription[J]. Neuroscience, 2008, 156(3): 630-639.
[69] Da Silva RS, Richetti SK, Silveira VG, et al. Maternal caffeine intake affects acetylcholinesterase in hippocampus of neonate rats[J]. International Journal of Developmental Neuroscience, 2008, 26(3-4): 339-343.
[70] Marret S, Gressens P, Van-Maele-Fabry G, et al. Caffeine-induced disturbances of early neurogenesis in whole mouse embryo cultures[J]. Brain Research, 1997(773): 213-216.
[71] Katsuki Y, Nakada S, Yokoyama T, et al. Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes[J]. Cancer Science, 2008, 99(8): 1539-1545.

The Physiological Functions of Caffeine and Their Related Mechanisms

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10

[1]	SUN Yue, WU Jun, WEI Chaoling, LIU Mengyue, GAO Chenxi, ZHANG Lingzhi, CAO Shixian, YU Shuntian, JIN Shan, SUN Weijiang. Screening of Tea Germplasm Resistant to Matsumurasca onukii and Dendrothrips minowai Priesner and Analysis of Resistance-related Factors [J]. Journal of Tea Science, 2022, 42(5): 689-704.
[2]	FANG Mengrui, LÜ Jun, RUAN Jianyun, BIAN Lei, WU Chuanyu, YAO Qing. Tea Buds Detection Model Using Improved YOLOv4-tiny [J]. Journal of Tea Science, 2022, 42(4): 549-560.
[3]	XING Anqi, WU Zichen, XU Xiaohan, SUN Yi, WANG Genmei, WANG Yuhua. Research Advances of Fluoride Accumulation Mechanisms in Tea Plants (Camellia sinensis) [J]. Journal of Tea Science, 2022, 42(3): 301-315.
[4]	ZHANG Zhipeng, CHENG Qinghua, XIE Jingkang, WAN Yuhe, TONG Huarong, CHEN Yingjuan. The Antifungal Effect and Mechanism of Berberine on Different Colletotrichum Species Causing Tea Brown Blight Disease [J]. Journal of Tea Science, 2022, 42(3): 367-375.
[5]	DONG Yanru, CAO Yanyan, LU Jiachun, MEI Sifan, HE Run, CHEN Ping. Crystallographic Study on the Complex of Catechins and Caffeine [J]. Journal of Tea Science, 2021, 41(1): 80-89.
[6]	OUYANG Jian, ZHOU Fang, LU Danmin, LI Xiuping, HUANG Jian'an, LIU Zhonghua. Research Progress of Tea Polysaccharides in Regulating Obesity [J]. Journal of Tea Science, 2020, 40(5): 565-575.
[7]	ZENG Jie, DENG Zhihui, FU Hongjuan, LIU Chang, GU Yi, ZOU Yixin, CHANG Hui. Theaflavin Activates Nrf2/HO-1 Pathway to Alleviate Oxidative Stress Injury in Vascular Endothelial Cells [J]. Journal of Tea Science, 2020, 40(5): 632-640.
[8]	LU Li, CHENG Xi, ZHANG Bo, SHEN Xiaoxia, LIU Yan, XIONG Li, YUAN Xiao, LI Yuanhua, LI Xinghui. Establishment of Predictive Model for Quantitative Analysis of Tea Polyphenols and Caffeine of Souchong by Near Infrared Spectroscopy [J]. Journal of Tea Science, 2020, 40(5): 689-695.
[9]	GAO Chenxi, HUANG Yan, SUN Weijiang. Research Progress of Proanthocyanidins in Tea [J]. Journal of Tea Science, 2020, 40(4): 441-453.
[10]	ZHENG Chengqin, MA Cunqiang, ZHANG Zhengyan, LI Xiaohong, WU Tingting, ZHOU Binxing. A Preliminary Study on the Degradation Pathway of Caffeine in Tea Microbial Solid-state Fermentation [J]. Journal of Tea Science, 2020, 40(3): 386-396.
[11]	XU Jiajia, GUANG Min, SHI Shulin, GAO Hongjian. Physiological and Molecular Mechanisms of Transmembrane Fluoride Uptake by Tea Roots [J]. Journal of Tea Science, 2019, 39(4): 365-371.
[12]	LIU Sai, LIU Shuoqian, LONG Jinhua, WU Dunchao, CHEN Yuhong, LIU Liping, LIU Zhonghua, TIAN Na. Functional Analysis of Glutathione Peroxidase Encoding Gene CsGPX1 in Camellia sinensis [J]. Journal of Tea Science, 2019, 39(4): 382-391.
[13]	ZENG Li, XIAO Wenjun. Advances in Brain Diseases Prevention and Treatment of L- theanine [J]. Journal of Tea Science, 2019, 39(2): 193-202.
[14]	HUANG Danjuan, MAO Yingxin, CHEN Xun, TAN Rongrong, WANG Hongjuan, WANG Youping, GONG Ziming. Advances in Aluminum Accumulation and Tolerance Mechanisms in Tea Plant (Camellia sinensis) [J]. Journal of Tea Science, 2018, 38(2): 125-132.
[15]	LIU Fei, WANG Yun, ZHANG Ting, TANG Xiaobo, WANG Xiaoping, LI Chunhua. Review on Aroma Change during Black Tea Processing [J]. Journal of Tea Science, 2018, 38(1): 9-19.