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Journal of Tea Science ›› 2011, Vol. 31 ›› Issue (1): 22-26.doi: 10.13305/j.cnki.jts.2011.01.004

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Clinical Observation of Tea Polyphenol Tablet on Chronic Glomerulonephritis

WANG Yue-fei1, SHI Xiao-yun1, XU Ping1, WANG Guan-qiao2, WU Zheng-qi3, YANG Xian-qiang1   

  1. 1. Department of Tea Science, Zhejiang University, Hangzhou 310029, China;
    2. The First People’s Hospital of Xiaoshan, Hangzhou 311200, China;
    3. Hubei Chinese medicine Institute, Wuhan 430065, China
  • Received:2010-04-01 Revised:2010-08-02 Online:2011-02-15 Published:2019-09-06

Abstract: To evaluate the efficiency and safety of tea polyphenol tablet on chronic glomerulonephritis in clinic, a multi-centre, prospective, double-blind and double-mimicry, positive control (shenyan siwei tablet) trial was conducted, and 240 patients (120 patients of treated group and 120 patients of control group) was observed for 8 weeks. After 8 weeks’ treatment, the efficacy in cured rate of relieving clinical symptoms of patiens, the scores of symptoms efficacy, urinary protein efficacy and urine erythrocyte efficacy were 35.0%, 38.5%, 49.6% and 59.7% respectively in tea polyphenol tablet group, and the total effective rate were 71.8%, 86.1%, 80.0% and 72.6% respectively. It showed no difference comparing with positive control group. No adverse effects appeared during the trial, both tea polyphenol tablet and shenyan siwei tablet were evaluated as first-level safety by the patients of trial group and positive control group. All results suggested that tea polyphenol tablet is an efficient and safe drug in treatment of chronic glomerulonephritis, and its efficacy is not less than shenyan siwei tablet.

Key words: tea polyphenols, glomerulonephritis, chronic, clinical

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