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Journal of Tea Science ›› 2014, Vol. 34 ›› Issue (5): 442-450.doi: 10.13305/j.cnki.jts.2014.05.004

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Research on the Protection and Mechanism of Pu'er Tea on the Renal Inflammation Injury Resulted by Chronic Lead Treatment

LIU Hongjuan1,2, LYU Cui1,2, LIU Xiaoli1,2, ZUO Ru3, SHENG Jun4, ZHANG Wensheng1,2,*   

  1. 1. State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China;
    2. Protection and Utilization of Chinese Medicine Resources of Beijing Key Laboratory, Beijing Normal University, Beijing 100875, China;
    3. Hebei College of Traditional Chinese Medicine, Hebei University, Baoding 071000, China;
    4. Molecular Biology Laboratory of Yunnan Agricultural University, Kunming 650201, China
  • Received:2013-11-04 Revised:2013-12-11 Published:2019-09-03

Abstract: Lead (Pb) is one of the most important inorganic contaminants in the environment, which can cause multiple systems and multiple organs damage. Kidney is the main target organ for lead toxicity. Lead can cause renal glomerular damage, leading to renal interstitial fibrosis, and causing renal inflammation injury. Renal inflammation injury is current research focus, whose main mechanism is oxidative stress and cell apoptosis, etc. Preliminary study found that chronic lead exposure can cause the renal inflammation injury though increasing Methylglyoxal(MG). MG is a dicarbonyl compounds distributed widely, with a high activity in reacting with nucleobase of DNA, RNA and residue of protein. Accumulation of MG can promote inflammatory injury through AGES-RAGE-NFκB pathway. Pu’er tea is Characteristic, it can remove MG producing by high glucose. In this study, Different doses of Pu’er tea were used to treat the lead exposure model, then detecting the whole blood lead level, inflammatory factor TNF-α, 1L-1β, RGAE protein expression and carbonyl compounds MG levels of kidney tissues of mouse. The results showed that a certain concentration of Pu’er tea can not only play pro-excretion effect, but also directly chelate the MG in organ, reduces the excessive accumulation of MG, and the formation of AGEs, down-regulate the expression of RAGE, and reduce the generation of TNF-α, 1L-1β, finally slowing subsequent inflammatory injury.

Key words: Pu'er tea, Chronic lead exposure, renal injury, methylglyoxal(MG), RAGE, NFкB, TNF-α, 1L-1β

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