茯砖茶提取物对葡聚糖硫酸钠诱导小鼠炎症性肠病的保护作用研究

doi:10.13305/j.cnki.jts.2019.06.003

Abstract

Abstract: Fu brick tea is a special dark tea in China. In the present work, three extracts, including Fu brick tea water extract (FWE), Fu brick tea ethanol soluble fraction (FES) and Fu brick tea ethanol precipitation fraction(FEP), were prepared and used to further explore their protective effects on inflammatory bowel disease in mice. Researches show that all the Fu brick tea extracts could alleviate the intestinal structure damage of IBD mice. Moreover, the extracts increased the activities of SOD, CAT and the levels of GSH and reduced the levels of IL-6, IL-1β, TNF-α in serum and colon tissue supernatant of mice. Furthermore, the protein level of NF-κB p65 in the colon tissues in the FWE group was decreased compared to the model group. The protein level of IκBα was increased in the FWE group and FES group. Levels of Nrf2 and HO-1 were also increased in the FWE and FES groups. In conclusion, Fu brick tea extracts had a protective effect on IBD mice induced by DSS.

Key words: Fu brick tea, inflammatory bowel disease, inflammation, oxidative stress

CLC Number:

S571.1
R574

HU Ankai, YAO Liyun, ZHAO Yueling, LIU Chang, WANG Yuefei, XU Ping. Protective Effects of Fu Brick Tea Extracts on Inflammatory Bowel Disease Induced by Dextran Sulfate Sodium in Mice[J]. Journal of Tea Science, 2019, 39(6): 641-651.

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Protective Effects of Fu Brick Tea Extracts on Inflammatory Bowel Disease Induced by Dextran Sulfate Sodium in Mice

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