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Journal of Tea Science ›› 2010, Vol. 30 ›› Issue (1): 13-18.doi: 10.13305/j.cnki.jts.2010.01.003

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Experiment on Safety of Ectropis grisescens Nucleopolyhedrovirus(EgNPV)

GONG Zi-ming1,3, LIU Ming-yan1,3, TAN Rong-rong1,3, MAO Ying-xin1,3, LI Long2, CHEN Guo-hua2, ZHOU Zheng-min2, LI Xiao-wen2   

  1. 1. Institute of Fruit & Tea, Hubei Academy of Agricultural Sciences, Wuhan 430209, China;;
    2. Research Center of Toxicology in Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
    3. Hubei Tea Engineering and Technology Research Centre, Wuhan 430209, China
  • Received:2008-08-25 Revised:2009-07-07 Published:2019-09-10

Abstract: A series of toxicological researches conducted in this study. the acute toxicity test, the eyes and skin stimulative test on rabbit, the skin sensitivity test on Guinea pig and the acute pathogenic test on mice. According to the experimental results of acute oral toxicity (LD50>5 000 mg/kg) and acute dermal toxicity(LD50>2 000 mg/kg), the acute toxicity of EgNPV on mice belongs to the category of low toxicity. It is not only non-irritating to skin but also has no stimulation on eyes of rabbits. The sensitization rate was 0%, did not cause hypersensitic reaction on Guinea pig. The results of histopathological test showed that no pathological changes were found in internal organs of mice in each experimental groups.

Key words: Ectropis grisescens, nucleopolyhedrovirus, toxicity, safety test

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