白茶寿眉预防小鼠肥胖作用研究及安全性评价

Abstract

Abstract: White tea extracts (WTEs) had been prepared from Shoumei white tea stored for 1, 3 and 7 years, respectively. Male mice (C57BL/6J) were fed with high-fat diet and supplemented with WTE to establish the anti-obesity efficacy model. Body weight gain, food intake, the pathobiology changes of the liver and adipose tissues, serum lipids profiles and differential expression profiles of lipid metabolism-related genes of liver in mice were investigated. The results showed that WTEs inhibited adipocyte differentiation and lipid excessive accumulation in adipose tissues, inhibited fatty acid synthesis and lipid excessive accumulation in liver by ameliorating the expression levels of lipid metabolism-related genes via down-regulation of the mRNA expression level of SREBP-1c, FAS and ACC1, thus depressing the increase of body weight and adipose tissues induced by high-fat diet. The preventing obesity efficacy of Shoumei white tea in high dosage was reduced with the increase of the storage years..

Key words: white tea, anti-obesity, safety

CLC Number:

ZHENG Li, HOU Caiyun, REN Fazheng. Anti-obesity Efficacy of Shoumei White Tea on High-fat Diet Mice and Its Safety Evaluation[J]. Journal of Tea Science, 2017, 37(6): 586-596.

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Anti-obesity Efficacy of Shoumei White Tea on High-fat Diet Mice and Its Safety Evaluation

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