高通量筛选研究茯砖茶降脂功效

doi:10.13305/j.cnki.jts.2006.03.011

Abstract

Abstract: Searching high effective and natural medicines for therapy for hyperlipidemia is one of the focus of research. High-Throughput Screening is a kind of new technique of medicine screening. The water extractions of FUZHUAN Tea were extracted by chloroform, ethyl acetate, 1-butanol separately. The samples were used to test their function of adjusting fat metabolism of FUZHUAN Tea by the models of PPARα, PPARγ, PPARδ, LXR, FXR and 3T3-L1 of High-Throughput Screening. The results showed that FUZHUAN Tea could activate PPARγ, PPARδ and restrain FXR. Its effect to PPRAα and 3T3-L1 was not obvious. FUZHUAN Tea was effective in therapy for hyperlipidemia. The active components need to be separated later.

Key words: Fuzhuan Tea, PPARα, PPARγ, PPARδ, LXR, FXR, 3T3-L1, high-Throughput Screening

CLC Number:

FU Dong-he, LIU Zhong-hua, HUANG Jianan, GONG Yu-shun, CHEN Jin-hua. Research of FUZHUAN Tea’s Therapy for Hyperlipidemia by High-Throughput Screening[J]. Journal of Tea Science, 2006, 26(3): 209-214.

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Research of FUZHUAN Tea’s Therapy for Hyperlipidemia by High-Throughput Screening

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