Abstract: The objective of the study is to investigate the protective effects of tea polyphenol (TP) on injury of skin tissue of mice induced by linear alkylbenzene sulfonate (LAS). Fifty healthy Kunming mice (male) were randomly divided into 5 groups including normal control group (NC), TP control group (TPC), LAS-injury group (LAS, 300 mg·L^-1), TP-intervention group 1 (LAS 300 mg·L^-1, TP 100 mg·L^-1) and TP-intervention group 2 (LAS 300 mg·L^-1, TP 200 mg·L^-1) respectively (n=10). The skins on the back of all mice were shaved and treated with distilled water and different concentrations of LAS and TP for 60 days. The observational indexes included general condition of mice , HE and Masson staining of skin, the levels of malondialdehyde (MDA), super oxidase dimutase (SOD), glutathione peroxidase (GSH-Px), hydroxyproline (Hyp), lactate dehydrogenase (LDH) and nitric oxide (NO) in skin and serum. The results showed that administration of TP to LAS-treated mice inhibited the oxidative stress and destruction of collagen fiber of skin induced by LAS. Compared with LAS-injury group, the body weight and skin

Key words: tea polyphenol, linear alkylbenzene sulfonate, skin tissue, injury, protection