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茶叶科学 ›› 2006, Vol. 26 ›› Issue (2): 122-127.doi: 10.13305/j.cnki.jts.2006.02.009

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绿茶口含片安全性毒理学研究

宿迷菊, 王岳飞*, 骆耀平, 李靓, 杨贤强   

  1. 浙江大学茶学系,浙江 杭州 310029
  • 收稿日期:2005-09-15 修回日期:2005-09-27 出版日期:2006-06-25 发布日期:2019-09-10
  • 通讯作者: * 王岳飞
  • 作者简介:宿迷菊,女(1981- ),山东菏泽人,浙江大学硕士研究生,主要从事茶叶生化与综合利用方面研究。

Toxicological Research of the Edible Safety of Green Tea Buccal Tablets

SU Mi-ju, WANG Yue-fei*, LUO Yao-ping, LI Liang, YANG Xian-qiang   

  1. Department of Tea Science, Zhejiang University, Hangzhou 310029, China
  • Received:2005-09-15 Revised:2005-09-27 Online:2006-06-25 Published:2019-09-10

摘要: 为检测绿茶口含片的食用安全性,通过急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)、30βd喂养试验进行毒理学研究。结果雌雄两性大、小鼠经口MTD均大于20.0βg/kg体重,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验三项遗传毒性试验结果均为阴性,显示无致突变性。30βd喂养试验(5.00βg/kg体重)未见动物出现中毒症状。结论绿茶口含片急性毒性分级属无毒级、无遗传毒性,试验中最大无损害作用剂量大于5βg/kg体重,食用安全性高。

关键词: 绿茶口含片, 急性毒性, 最大耐受量, 遗传毒性, 安全性

Abstract: To evaluate the edible safety of green tea buccal tablets(GTBT), tests included acute toxicity test, Aames test, Micronucleus test, Sperm shape abnormality test and thirty days feeding test were performed. Results shows that: The oral maximum tolerated dose(MTD) was higher than 20.0βg/kg·bw both in male or female mice and rats. Ames test, Micronucleus test and Sperm shape abnormality test were positive. No significant toxicity was detected in thirty days feeding test. Conclusion: Green tea buccal tablets has no acute toxicity, no genotoxicity, high in edible safety.

Key words: green tea buccal tablets, acute toxicity, maximum tolerated dose, genotoxicity, edible safety

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