湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响

李世刚; 郑倩倩; 何建刚; 肖长义; 柳蔚; 王慧; 刘锦程

doi:10.13305/j.cnki.jts.2016.03.003

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茶叶科学 ›› 2016, Vol. 36 ›› Issue (3) : 245-249. DOI: 10.13305/j.cnki.jts.2016.03.003

湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响

李世刚^1,2, 郑倩倩², 何建刚¹, 肖长义^1,2, 柳蔚^1,2, 王慧^1,3, 刘锦程¹

作者信息 +

The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

LI Shigang^1,2, ZHENG Qianqian², HE Jiangang¹, XIAO Changyi^1,2, LIU Wei^1,2, WANG Hui^1,3, LIU Jincheng¹

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文章历史 +

摘要

研究了湖北青砖茶对腹泻型肠易激综合征（IBS-D）模型大鼠肠道的影响。结果表明,与正常组相比,模型组的痛阈值明显降低,血清中炎症因子前列腺素2（PGE2）、肿瘤坏死因子（TNF-α）、类胰蛋白酶的含量明显增加;与模型组比较,湖北青砖茶低剂量组、高剂量组能够显著升高痛阈值,而血清中炎症因子PGE2、TNF-α、类胰蛋白酶的含量显著降低,且具有剂量依赖性。由此表明湖北青砖茶可降低IBS-D模型大鼠的肠道敏感性,其作用机制可能与血清中PGE2、TNF-α和类胰蛋白酶含量的降低有关。

Abstract

The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels.

导出引用

李世刚, 郑倩倩, 何建刚, 肖长义, 柳蔚, 王慧, 刘锦程. 湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响[J]. 茶叶科学. 2016, 36(3): 245-249 https://doi.org/10.13305/j.cnki.jts.2016.03.003

LI Shigang, ZHENG Qianqian, HE Jiangang, XIAO Changyi, LIU Wei, WANG Hui, LIU Jincheng. The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model[J]. Journal of Tea Science. 2016, 36(3): 245-249 https://doi.org/10.13305/j.cnki.jts.2016.03.003

中图分类号： S571.1 O614.23+1

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