Review on the Studies about Safety Assessment of Pu-erh Tea

MA Yan; CHEN Lijiao; LYU Caiyou; ZHAO Ming

doi:10.13305/j.cnki.jts.2018.03.001

PDF(622 KB)

Journal of Tea Science ›› 2018, Vol. 38 ›› Issue (3) : 221-226. DOI: 10.13305/j.cnki.jts.2018.03.001

Review on the Studies about Safety Assessment of Pu-erh Tea

MA Yan, CHEN Lijiao, LYU Caiyou, ZHAO Ming^*

Author information +

History +

Abstract

Toxicology assessment is an important index to evaluate food safety. To provide scientific references for the evaluation of safety of Pu-erh tea, relative studies were reviewed. The acute oral toxicity tests showed that the LD₅₀ of Pu-erh tea was great than 5β000βmg·kg^-1, which belonged to the actual non-toxic level. The no-observed-adverse-effect-levels of non-fermented and post-fermented Pu-erh tea were 1β250βmg·kg^-1·d^-1 and 5β000βmg·kg^-1·d^-1 in 28βd or 90βd administration tests. Pu-erh tea showed no mutagenicity on the primitive, authentic and reproductive cells during genetic toxicity evaluation. The no-observed-adverse-effect level of Pu-erh tea was 700βmg·kg^-1·d^-1 for both reproductive and developmental toxicities. Little or none toxicity of Pu-erh tea to mice liver cells was observed. No pathological change was observed in human acute and subacute toxicity assays. In conclusion, the toxicology assessments proved the safety of Pu-erh tea.

Key words

food safety / Pu-erh tea / toxicological assessment

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

MA Yan, CHEN Lijiao, LYU Caiyou, ZHAO Ming. Review on the Studies about Safety Assessment of Pu-erh Tea[J]. Journal of Tea Science. 2018, 38(3): 221-226 https://doi.org/10.13305/j.cnki.jts.2018.03.001

References

[1] 李宁. 国内食品安全性毒理学评价的现状和发展[J]. 毒理学杂志, 2007, 21(5): 368-370.
[2] 张婧, 张晓鹏, 贾旭东, 等. 我国食品毒理学评价程序和方法标准现况与管理对策[J]. 毒理学杂志, 2015, 29(2): 109-113.
[3] 中华人民共和国国家卫生和计划生育委员会. 食品安全国家标准食品安全性毒理学评价程序:GB 15193.1—2014[S]. 2014.
[4] 郑晓燕, 张倩茹. 普洱茶发酵过程中微生物研究现状[J]. 食品安全导刊, 2017, 23: 26-27.
[5] 马燕, 张冬莲, 苏小琴, 等. 茶叶中真菌毒素污染的国内外研究概况[J]. 中国食品卫生杂志, 2014, 26(6): 627-630.
[6] 刘勤晋, 陈文品, 白文祥, 等. 普洱茶急性毒性安全性评价研究报告[J]. 茶叶科学, 2003, 23(2): 141-145.
[7] 中华人民共和国国家卫生和计划生育委员会. 食品安全国家标准急性经口毒性试验. GB 15193.3—2014[S]. 2014.
[8] 陈文品, 刘勤晋, 白文祥, 等. 普洱茶毒理学安全性评价研究[Z]. 杭州: 2004, 09.
[9] 陈文品. 经典遗传毒理学试验表明普洱茶抗癌不致癌[J]. 普洱, 2012, 5: 80-85.
[10] 龚加顺, 陈文品, 周红杰, 等. 云南普洱茶特征成分的功能与毒理学评价[J]. 茶叶科学, 2007, 27(3): 201-210.
[11] 陈娜, 侯艳, 徐昆龙, 等. 云南普洱茶急性毒性研究[J]. 云南农业大学学报, 2008, 23(2): 233-237.
[12] 胡雪婷. 普洱茶毒理学的初步研究[D]. 武汉: 华中科技大学, 2009.
[13] 马伟光, 黄之镨, 游文龙, 等. 配方普洱茶的急性毒性研究[J]. 茶叶科学, 2010, 30(1): 9-12.
[14] Wang D, Xu K, Zhong Y, et al.Acute and subchronic oral toxicities of Pu-erh black tea extract in sprague-dawley rats[J]. Journal of Ethnopharmacology, 2011, 134(1): 156-164.
[15] 梁名志, 王丽, 王立波,等. 人工接种真菌固态发酵普洱茶的急性毒性安全性评价[J]. 西南农业学报, 2012, 25(05): 1956-1958.
[16] 吴婧, 孙世利, 徐平, 等. 普洱茶抗氧化制剂毒理学研究与安全性评价[J]. 中国茶叶加工, 2014, 4: 18-24.
[17] Fujita H, Yamagami T.Efficacy and safety of Chinese black tea (Pu-ehr) extract in healthy and hypercholesterolemic subjects[J]. Annals of Nutrition and Metabolism, 2008, 53(1): 33-42.
[18] 中华人民共和国国家卫生和计划生育委员会. GB 15193. 22-2014 食品安全国家标准 28天经口毒性试验[S]. 2014.
[19] Wang D, Xiao R, Hu X, et al.Comparative safety evaluation of Chinese Pu-erh green tea extract and Pu-erh black tea extract in Wistar rats[J]. Journal of Agricultural and Food Chemistry, 2010, 58(2): 1350-1358.
[20] 中华人民共和国国家卫生和计划生育委员会. 食品安全国家标准 90天经口毒性试验:GB 15193.13—2015[S]. 2015.
[21] 李艳艳, 肖蓉, 江波, 等. 普洱茶对SD大鼠血液生理生化指标影响的研究[J]. 云南农业大学学报(自然科学版), 2011, 26(2): 254-259.
[22] 陈文品, 刘勤晋, 白文祥, 等. 普洱茶遗传毒性安全性评价研究[J]. 茶叶科学, 2005, 25(3): 208-212.
[23] Wu S, Yen G, Wang B, et al.Antimutagenic and antimicrobial activities of Pu-erh tea[J]. LWT - Food Science and Technology, 2007, 40(3): 506-512.
[24] Wang D, Meng J, Gao H, et al.Evaluation of reproductive and developmental toxicities of Pu-erh black tea (Camellia sinensis var. assamica) extract in Sprague Dawley rats[J]. Journal of Ethnopharmacology, 2013, 148(1): 190-198.
[25] 李红霞, 孙永科, 李艳艳, 等. 普洱茶对原代小鼠肝细胞的毒性初探[J]. 食品工业科技, 2010, 31(12): 322-325.
[26] 王迪. 氧化应激介导的喹烯酮遗传毒性及普洱茶水提取液保护作用研究[D]. 武汉: 华中科技大学, 2011.
[27] Hwang L S, Lin L, Chen N, et al.Hypolipidemic effect and antiatherogenic potential of Pu-Erh tea[M]. ACS Symposium Series, 2003, 859: 87-103.
[28] Kubota K, Sumi S, Tojo H, et al.Improvements of mean body mass index and body weight in preobese and overweight Japanese adults with black Chinese tea (Pu-Erh) water extract[J]. Nutrition Research, 2011, 31(6): 421-428.
[29] Chu S, Fu H, Yang J, et al.A randomized double-blind placebo-controlled study of Pu'er tea extract on the regulation of metabolic syndrome[J]. Chinese Journal of Integrative Medicine, 2011, 17(7): 492-498.
[30] Yang T, Chou J I, Ueng K, et al.Weight reduction effect of pu-erh tea in male patients with metabolic syndrome[J]. Phytotherapy Research. 2014, 28(7): 1096-1101.