陈虎，胡英，周睿，赵剑 . Review on Antioxidative Mechanism of Theaflavins[J]. Journal of Tea Science, 2005 , 25(4) : 237 -241 . DOI: 10.13305/j.cnki.jts.2005.04.001

[1] Graham H N. Green tea composition, consumption, and polyphenol[J]. chemistry Prev Med, 1992, 21: 334~350.
[2] Rice-Evans C A, Miller N J, Paganga G. Antioxidant properties of phenolic compounds[J]. Trends Plant Sci, 1997, 2: 152~159.
[3] Hollman P C H, Hertog M G L, Katan M B. Analysis and health effects of flavonoids[J]. Food Chem, 1996, 57: 43~46.
[4] Rice-Evans C A. Structure-anti-oxidant activity relationships of flavonoids and phenolic acids[J]. Free Radic Boil Med, 1996, 20: 933~956.
[5] Jovanavic S V, Steenken S, Simic M G. Antioxidant potentials of flavonoid and model phenoxyl radicals[J]. J Chem Soc Perkins Trans, 1996, 2: 2497~2503.
[6] Jovanavic S V, Hara Y, Steenken S, et al. Antioxidant potential of theaflavins. A pulse radiolysis study[J]. J. Am. Chem. Soc. 1997, 119: 5337-5343
[7] Saha P, Das S. Regulation of hazardous exposure by protective exposure: modulation of phase II detoxification and lipid peroxidation by Camellia sinensis and Swertia chirata[J]. Teratog Carcinog Mutagen. 2003;Suppl 1:313~322.
[8] Saha P, Das S. Elimination of Deleterious Effects of Free Radicals in Murine Skin Carcinogenesis by Black Tea Infusion, Theaflavins & Epigallocatechin Gallate[J]. Asian Pac J Cancer Prev. 2002, 3(3): 225~230.
[9] Erba D, Riso P, Foti P, et al. Black tea extract supplementation decreases oxidative damage in Jurkat T cells[J]. Arch Biochem Biophys. 2003 Aug 15, 416(2): 196~201.
[10] Zhang G, Miura Y, Yagasaki K. Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity[J]. Cancer Lett. 2000 Oct 31, 159(2): 169~173.
[11] Lin JK, Chen PC, Ho CT, et al. Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate[J]. J Agric Food Chem. 2000 Jul;48(7): 2736-2743.
[12] Feng Q, Torii Y, Uchida K, et al. Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures[J]. J Agric Food Chem. 2002 Jan 2, 50(1): 213~220.
[13] Ying CJ, Xu JW, Ikeda K, et al. Tea polyphenols regulate nicotinamide adenine dinucleotide phosphate oxidase subunit expression and ameliorate angiotensin II-induced hyperpermeability in endothelial cells[J]. Hypertens Res. 2003 Oct, 26(10): 823~828.
[14] Darley-Usmar V, Halliwell B. Blood, radicals:Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system[J]. Pharm Res, 1996, 13: 649~662.
[15] Sarkar A, Bhaduri A. Black tea is a powerful chemopreventor of reactive oxygen and nitrogen species: comparison with its individual catechin constituents and green tea[J]. Biochem Biophys Res Commun. 2001 Jun 1, 284(1): 173~178.
[16] Lin YL, Tsai SH, Lin-Shiau SY, et al. Theaflavin-3,3'-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-kappaB in macrophages[J]. Eur J Pharmacol. 1999 Feb 19, 367(2~3):379~388.
[17] Pan MH, Lin-Shiau SY, Ho CT, et al. Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages[J]. Biochem Pharmacol. 2000, Feb 15, 59(4): 357~367.
[18] Das M, Chaudhuri T, Goswami SK, et al. Sur P, Vedasiromoni JR, Studies with black tea and its constituents on leukemic cells and cell lines[J]. Exp Clin Cancer Res. 2002, Dec, 21(4): 563~568
[19] Miller NJ, Castelluccio C, Tijburg L, et al. The antioxidant properties of theaflavins and their gallate esters--radical scavengers or metal chelators[J]. FEBS Lett. 1996, Aug 19, 392(1): 40~44.
[20] Vernon E, Steele, Gary J, et al. Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays[J]. Carcinogenesis, 2000, 21(1): 63~67.
[21] Yoshida H, Ishikawa T, et al, inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein[J]. Biochem Pharmacol. 1999, Dec 1, 58(11): 1695~1703
[22] Leung LK, Su Y, Chen R, et al. Theaflavins in black tea and catechins in green tea are equally effective antioxidants[J]. Nutr. 2001, Sep, 131(9): 2248~2251.
[23] Miura S, Watanabe J, Sano M, et al. Effects of various natural antioxidants on the Cu2+-mediated oxidative modification of low density lipoprotein[J]. Biol Pharm Bull. 1995 Jan, 18(1): 1~4.
[24] Sano M, Takahashi Y, Yoshino K, et al, Effect of tea (Camellia sinensis L.) on lipid peroxidation in rat liver and kidney: a comparison of green and black tea feeding[J]. Biol Pharm Bull. 1995, Jul, 18(7): 1006~1008
[25] 陈瑗, 周玫. 自由基医学[M]. 人民军医出版社, 1991.
[26] Brown JE, Khodr H, Hider RC, et al. Structural dependence of flavonoid interactions with Cu2+ ions: implications for their antioxidant properties[J]. Biochem J. 1998 Mar 15, 330 ( Pt 3): 1173~1178.