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茶叶科学 ›› 2006, Vol. 26 ›› Issue (2): 128-130.doi: 10.13305/j.cnki.jts.2006.02.010

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茶多酚对大鼠血管紧张素I转换酶(ACE)活性的影响

张波   

  1. 北京联合大学应用文理学院生物学系,北京 100083
  • 收稿日期:2005-12-09 修回日期:2006-03-13 出版日期:2006-06-25 发布日期:2019-09-10
  • 作者简介:张波(1962- ),女,四川宣汉人,博士,教授,主要研究方向:食品功能与毒理
  • 基金资助:
    北京联合大学应用文理学院生物活性物质和功能食品北京市重点实验室开放课题资助

Effects of Tea Polyphenols on the Activity of AngiotensinⅠ Converting Enzyme

ZHANG Bo   

  1. The Biology Department of College of Arts and Sciences of Beijng Union University,Beijing 100083, China
  • Received:2005-12-09 Revised:2006-03-13 Online:2006-06-25 Published:2019-09-10

摘要: 研究茶多酚对大鼠血管紧张素Ⅰ转换酶(angiotensinⅠ converting enzyme,ACE)活性的影响。血管紧张素Ⅰ在ACE的作用下,通过脱去C端His-Leu二肽,转化为有生物活性的血管紧张素Ⅱ,从而产生强升压作用。通过体外试验和体内试验研究茶多酚对大鼠ACE活性的影响效应。试验结果表明,随着茶多酚摄入量的增加(45βmg/kg,90βmg/kg,180βmg/kg),ACE活性显著降低(84.43±4.59βu/μl,75.17±6.85βu/μl,60.19±8.62βu/μl,P<0.05)说明茶多酚对大鼠ACE有抑制作用,从而有可能起到降低血压的作用。

关键词: 茶多酚, 血管紧张素Ⅰ转换酶;, 酶活性, 大鼠

Abstract: Effects of tea plyphenols on angiotensinⅠconverting enzyme(ACE) activity were studied in this paper. Activity of ACE were determined by in vivo and in vitro on rats. The concentrationof polyphenols were 0, 0.31, 0.62, 1.24, 2.48, 4.96βmmol/L in vitro and polyphenols concentrations were 0, 45, 90, 180βmg/kg in vivo. ACE activity decreased markedly with the increase of tea polyphenols level in vivo and in vitro test. Results showed that activity of ACE is inhibited by tea polyphenols in vivo and in vitro test and these results showed that tea polyphenols possess the function of reducing blood pressure possibly.

Key words: tea plyphenols, angiotensinⅠ converting enzyme (ACE);, enzyme activity, rat.

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