绿茶、EGCG预防及缓解香烟烟雾诱导COPD的研究进展

摘要/Abstract

摘要： 慢性阻塞性肺疾病是由吸烟引发的最常见肺部疾病之一。香烟烟雾诱导的氧化应激、炎症反应及蛋白酶/抗蛋白酶失衡与慢性阻塞性肺疾病的发生、恶化密切关联。饮用绿茶、摄入EGCG能够清除人体内活性氧自由基,预防及缓解其带来的一系列呼吸道疾病。本文总结了近10年来众多学者对绿茶、EGCG作用于慢性阻塞性肺疾病的研究文献,以期探讨绿茶、EGCG预防及缓解慢性阻塞性肺疾病的机理,提高人们对绿茶、EGCG预防及缓解慢性阻塞性肺疾病的认识。

关键词: 香烟烟雾, 氧化应激, COPD, 绿茶, EGCG

Abstract: Chronic obstructive pulmonary disease (COPD) is one of the most common diseases induced by cigarette smoking. Cigarette smoke-induced oxidative stress, inflammation response, proteases and anti-proteases imbalance are intimately associated with the occurrence and exacerbation of COPD. Green tea consumption and EGCG oral administration can scavenge reactive oxygen species and free radicals in the human body, and inhibit a series of respiratory diseases caused by reactive oxygen species and free radicals. In this article, the research advance of the effects of green tea and EGCG on COPD for the past 10 years was reviewed in the purpose of exploring the mechanism and improving public knowledge of the preventing effects of green tea and EGCG on COPD.

Key words: cigarette smoke, oxidative stress, COPD, green tea, EGCG

中图分类号:

黄翔翔, 杨哲, 禹利君. 绿茶、EGCG预防及缓解香烟烟雾诱导COPD的研究进展[J]. 茶叶科学, 2017, 37(4): 332-338.

HUANG Xiangxiang, YANG Zhe, YU Lijun. Research Progress of Green Tea and EGCG for the Prevention and Mitigation of Chronic Obstructive Pulmonary Disease Caused by Cigarette Smoke[J]. Journal of Tea Science, 2017, 37(4): 332-338.

参考文献 42

[1]	Colin D Mathers, Dejan Loncar.Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med, 2006, 3(11): 2011-2030. doi: org/10.1371/journal. pmed. 0030442.
[2]	UGENSKIENE R, SANAK M, SAKALAUSKAS R, et al.Genetic polymorphisms in chronic obstructive pulmonary disease[J]. Medicina (Kaunas, Lithuania), 2005, 41(1): 17-22.
[3]	KRAUSS-ETSCHMANN S, MEYER K F, DEHMEL S, et al.Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?[J]. Clinical Epigenetics, 2015, 7: 53.
[4]	LANIADO-LABOR N R. Smoking and chronic obstructive pulmonary disease (COPD). Parallel epidemics of the 21st century[J]. International Journal of Environmental Research and Public Health, 2009, 6(1): 209-224.
[5]	Shaddick Gavin, Toledano Mireille B, Ward Helen.Oxford handbook of epidemiology for clinicians [M]. New York: Oxford University Press, 2012, 289-290.
[6]	SHARMA A.COPD in primary care [M]. UK: Radcliff Publishing, 2010
[7]	RENNARD S.Clinical management of chronic obstructive pulmonary disease [M]. 2nd. Boca Raton (FL): CRC Press/Taylor & Francis, 2007
[8]	HAKIM I A, CHOW H H, HARRIS R B.Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype[J]. The Journal of Nutrition, 2008, 138(8): 1567S-1571S.
[9]	张俊敬, 罗云峰, 颜景奇, 等. 咖啡和绿茶的抗氧化活性研究[J]. 生物物理学报, 2008, 24(6): 435-444.
[10]	SAIWICHAI T, SANGALANGKARN V, KAWAHARA K, et al.Green tea extract supplement inhibition of HMGB1 release in rats exposed to cigarette smoke[J]. The Southeast Asian Journal of Tropical Medicine and Public Health, 2010, 41(1): 250-258.
[11]	LI Q, ZHAO H, ZHAO M, et al.Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice[J]. Brain Research, 2010, 1353: 28-35.
[12]	顾成波, 袁肖寒, 付玉杰, 等. 绿茶EGCG防癌作用的分子靶点[J]. 茶叶科学, 2010, 30(6): 414-422.
[13]	CHAN K H, CHAN S C, YEUNG S C, et al.Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity[J]. Free Radical Research, 2012, 46(9): 1123-1129.
[14]	HESSIEN M, EL-GENDY S, DONIA T, et al.Growth inhibition of human non-small lung cancer cells h460 by green tea and ginger polyphenols[J]. Anti-cancer Agents in Medicinal Chemistry, 2012, 12(4): 383-390.
[15]	KUMAR M, SHARMA V L, SEHGAL A, et al.Protective effects of green and white tea against benzo(a)pyrene induced oxidative stress and DNA damage in murine model[J]. Nutrition and Cancer, 2012, 64(2): 300-306.
[16]	LIN I H, HO M L, CHEN H Y, et al.Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk[J]. PloS One, 2012, 7(2): e30951.
[17]	王婧, 陈信义, 侯丽, 等. 茶多酚对小鼠Lewis肺癌移植瘤中NF-κB、COX-2、Survivin表达的影响[J]. 中国肺癌杂志, 2012, 15(5): 271-276.
[18]	AL-AWAIDA W, AKASH M, ABURUBAIHA Z, et al.Chinese green tea consumption reduces oxidative stress, inflammation and tissues damage in smoke exposed rats[J]. Iranian Journal of Basic Medical Sciences, 2014, 17(10): 740-746.
[19]	衣卫杰, 谢筱, 卜勇军, 等. 绿茶多酚可能通过促进自噬发挥肾脏保护作用[J]. 营养学报, 2016, 38(5): 481-485.
[20]	TABAK C, ARTS I C, SMIT H A, et al.Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the morgen study[J]. American Journal of Respiratory and Critical Care Medicine, 2001, 164(1): 61-64.
[21]	VESTBO J, HURD S S, AGUSTI A G, et al.Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary[J]. American Journal of Respiratory and Critical Care Medicine, 2013, 187(4): 347-365.
[22]	CAN U, YERLIKAYA F H, YOSUNKAYA S.Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease[J]. Journal of the Chinese Medical Association: JCMA, 2015, 78(12): 702-708.
[23]	DOMEJ W, OETTL K, RENNER W.Oxidative stress and free radicals in COPD—implications and relevance for treatment[J]. International Journal of Chronic Obstructive Pulmonary Disease, 2014, 9: 1207-1224.
[24]	BISWAS S, HWANG J W, KIRKHAM P A, et al.Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease[J]. Current Medicinal Chemistry, 2013, 20(12): 1496-1530.
[25]	SHANMUGAM T, SELVARAJ M, POOMALAI S.Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study[J]. International Immunopharmacology, 2016, 39: 128-139.
[26]	SHI J, DENG H P, PAN H C, et al.Epigallocatechin-3-gallate attenuates microcystin-LR induced oxidative stress and inflammation in human umbilical vein endothelial cells[J]. Chemosphere, 2017, 168: 25-31.
[27]	HOLZER N, BRAUN K F, EHNERT S, et al.Green tea protects human osteoblasts from cigarette smoke-induced injury: possible clinical implication[J]. Langenbeck's Archives of Surgery, 2012, 397(3): 467-474.
[28]	CHAN K H, HO S P, YEUNG S C, et al.Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats[J]. Respiratory Medicine, 2009, 103(11): 1746-1754.
[29]	卿春华, 陈平, 向旭东. 茶多酚对低剂量烟草悬凝物诱导人支气管上皮细胞氧化损伤及凋亡的影响[J]. 中南大学学报: 医学版, 2010, 35(2): 123-128.
[30]	顾其华, 胡成平, 陈琼, 等. 绿茶对苯并芘诱发大鼠肺癌的预防及其机制初探[J]. 中国肺癌杂志, 2008, 11(4): 519-523.
[31]	MARCH T H, WILDER J A, ESPARZA D C, et al.Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice[J]. Toxicological Sciences: An Official Journal of the Society of Toxicology, 2006, 92(2): 545-559.
[32]	XIAOKAITI Y, WU H, CHEN Y, et al.EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating alpha1-AT[J]. Scientific Reports, 2015, 5: 11494.
[33]	CHEN X, LI W, WANG H.More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines[J]. Medical Hypotheses, 2006, 66(3): 660-663.
[34]	LI W, ZHU S, LI J, et al.EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages[J]. Biochemical Pharmacology, 2011, 81(9): 1152-1163.
[35]	PAL S, BHATTACHARJEE A, ALI A, et al.Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism[J]. J Inflamm-Lond, 2014, 11: 23
[36]	CHEN L, MO H, ZHAO L, et al.Therapeutic properties of green tea against environmental insults[J]. The Journal of Nutritional Biochemistry, 2017, 40: 1-13.
[37]	SYED D N, AFAQ F, KWEON M H, et al.Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells[J]. Oncogene, 2007, 26(5): 673-682.
[38]	KHOI P N, PARK J S, KIM J H, et al.(-)-Epigallocatechin-3-gallate blocks nicotine-induced matrix metalloproteinase-9 expression and invasiveness via suppression of NF-kappaB and AP-1 in endothelial cells[J]. International Journal of Oncology, 2013, 43(3): 868-876.
[39]	OYAMA J-I, MAEDA T, SASAKI M, et al.Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers[J]. Internal Medicine, 2010, 49(23): 2553-2559.
[40]	LEE I T, LIN C C, LEE C Y, et al.Protective effects of (-)-epigallocatechin-3-gallate against TNF-alpha-induced lung inflammation via ROS-dependent ICAM-1 inhibition[J]. J Nutr Biochem, 2013, 24(1): 124-136.
[41]	MOLINA N, BOLIN A, OTTON R.Green tea polyphenols change the profile of inflammatory cytokine release from lymphocytes of obese and lean rats and protect against oxidative damage[J]. Int Immunopharmacol, 2015, 28(2): 985-996.
[42]	MARINOVIC M, MORANDI A, OTTON R.Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFκB p65 signal pathway[J]. Toxicol In Vitro, 2015, 29(7): 1766-1778.