本实验利用HCT-8及SGC-7901两种细胞株研究黑茶对消化道肿瘤细胞生长的抑制作用,结果发现,黑茶具有良好的抑制消化道肿瘤细胞生长的作用。黑茶中含有两种抑制活性物质,其中对SGC-7901细胞株具有抑制能力的物质的极性要比对HCT-8细胞株具有抑制能力的物质极性低一些。黑茶具有对两种细胞株抑制的功能可能是多种物质成分共同作用的结果,而中低极性的物质抑制能力较强。
Stomach cancer and intestinal cancer are the two common diseases of the alimentary canal tumor. HCT-8 and SGC-7901 cell are taken as model to study the activity of Dark Tea to Gastrointestinal Tumor. The results showed that Dark Tea has good inhibitory action to gastrointestinal tumor cell growth. Dark tea contained two active inhibitors for Gastrointestinal Tumor, and the inhibitor for SGC-7901 cell has low polar than the inhibitor for HCT-8. The inhibiting active of Dark Tea to the two cell models maybe comes from manifold physiological activators, and maybe the low polar substances have stronger power.
[1] Yu Tang Gao, Joseph K, McLaughlin, et al. Reduced Risk of Esophageal Cancer Associated With Green Tea Consumption[J]. JNCI Journal of the National Cancer Institute, 1994, 6(11): 855~858.
[2] YIN PINGZHANG, ZHAO JINYING, CHENG SHUJUN, et al. Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1 Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine[J]. Cancer letters, 1994, 79(1): 33~38 (28 ref.).
[3] 潘宏铭, 吴金民, 郑树, 等. 茶多酚对二甲肼诱发小鼠大肠肿瘤的抑制作用[J]. 中华预防医学杂志, 1995, 29(6): 356~359.
[4] Jain M, Howe GR, St Louis P, et al. Coffee and alcohol as determinants of risk of pancreas cancer: a case-control study from Toronto[J]. Int J Cancer, 1991, 47(3): 384~389.
[5] 张均田. 现代药理学实验方法(第一版)[M]. 北京: 北京医科大学中国协和医科大学联合出版社, 1998, 10.
[6] 宋鲁彬, 黄建安, 刘仲华, 等. 中国黑茶对PPARs的作用研究[J]. 茶叶科学, 2008, 28(5): 166~171.
[7] 杨贤强, 王岳飞, 陈留记. 茶多酚化学[M]. 上海: 上海科学技术出版社, 2003.
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