表没食子儿茶素没食子酸酯（EGCG）研究的文献计量分析

张旖旎; 吉铮

doi:10.13305/j.cnki.jts.20220416.002

茶叶科学 >

2022 , Vol. 42 >Issue 3: 423 - 434

DOI: https://doi.org/10.13305/j.cnki.jts.20220416.002

研究报告

表没食子儿茶素没食子酸酯（EGCG）研究的文献计量分析

张旖旎 ,
吉铮

展开

1.陕西师范大学地理科学与旅游学院,陕西西安 710119;
2.陕西师范大学地理学国家级实验教学示范中心,陕西西安 710119;
3.陕西师范大学环境科学专业省级实验教学示范中心,陕西西安 710119

张旖旎,女,硕士研究生,主要从事茶多酚高级氧化的环境应用研究。

收稿日期: 2021-10-19

修回日期: 2021-11-23

网络出版日期: 2022-06-17

基金资助

国家自然科学基金（52000127）、国家留学基金（201906875037）、陕西省自然科学基础研究计划（2017JQ5074）、西安市科技计划项目[2017071CG/RC034(SXSF002)]、中央高校基本科研业务费（GK201603075、GK201601009、GK201802108）

收起

Econometric Analyses of EGCG Research Literature

ZHANG Yini ,
JI Zheng

Expand

1. School of Geography and Tourism, Shaanxi Normal University, Xi'an 710119, China;
2. National Experimental Teaching Demonstration Center of Geography, Shaanxi Normal University, Xi'an 710119, China;
3. Provincial Experimental Teaching Demonstration Center of Environmental Science Major, Shaanxi Normal University, Xi'an 710119, China

Received date: 2021-10-19

Revised date: 2021-11-23

Online published: 2022-06-17

Fold

摘要

茶叶中的EGCG在治疗癌症、细菌和病毒感染等疾病中显示出较高的生物活性。为探索EGCG的相关研究进展及近期研究重点,以“EGCG”及“Epigallocatechin gallate”为主题词,在ISI Web of Science数据库核心合集搜索2000—2021年的相关文献共6 799篇,采用CiteSpace可视化软件进行引文分析,通过合作、共现、共被引等网络分析,研究EGCG的研究重点和前沿趋势。根据发文量统计分析发现,中国、美国和日本在该领域发文量排名前三位,而中介中心性指标分析表明美国、德国和中国文献重要性位列前三。引文分析的关键词突发性检测发现,“纳米粒子（Nanoparticle）”“稳定性（Stability）”是近几年的研究重点。随着对EGCG研究层次的不断深入,未来研究可能会集中于提高EGCG生物利用度,探究最适剂量水平及给药频率等方面。

关键词： CiteSpace; EGCG; 可视化分析; 网络分析

本文引用格式

张旖旎 , 吉铮 . 表没食子儿茶素没食子酸酯（EGCG）研究的文献计量分析[J]. 茶叶科学, 2022 , 42(3) : 423 -434 . DOI: 10.13305/j.cnki.jts.20220416.002

Abstract

The epigallocatechin gallate (EGCG) has shown the highest biological activity in tea components in most studies, which has shown beneficial effects on anti-cancer, bacterial and viral infections. A review of the advances and hot spots of EGCG studies were summarized through citation analysis. In order to ensure that the review is objective and scientific, literature analysis was performed from the core collection of the data base of ISI Web of Science of the period of 2000-2021 with the key words “EGCG” and “Epigallocatechin gallate”. A total of 6 799 relevant papers were obtained. Then, the CiteSpace visualization software was used for citation analysis and the research hotspots and frontier trends were studied through network analysis including cooperation, co-occurrence and co-citation. Statistical analysis of volume of the publications shows that China, United States and Japan ranked the top three in this field. Analysis of betweenness central indicators shows that United States, Germany and China were the top three in terms of importance. Further citation analysis shows that “nanoparticle”, and “stability” were the hotspots in the recent years. With the deepening of the research on EGCG, it was speculated that the future research would focus on improving the bioavailability of EGCG and exploring the optimal dose level and administration frequency.

Key words： CiteSpace; EGCG; network; visual analysis

参考文献

[1] 林智, 吕海鹏, 张盛. 茶叶活性成分的化学和药理作用[J]. 中国茶叶, 2018, 40(11): 1-6.
Lin Z, Lv H P, Zhang S.Chemical and pharmacological effects of active components of tea[J]. China Tea, 2018, 40(11): 1-6.
[2] Rady I, Mohamed H, Rady M, et al.Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea[J]. Egyptian Journal of Basic and Applied Sciences, 2018, 5(1): 1-23.
[3] 蔡静, 叶润, 贾凯, 等. 茶多酚的提取及抑菌活性研究综述[J]. 化学试剂, 2020, 42(2): 105-114.
Cai J, Ye R, Jia K, et al.Review on extraction and antibacterial activity of tea polyphenols[J]. Chemical Reagents, 2020, 42(2): 105-114.
[4] 李柯欣. 茶多酚的提取、抑菌作用与抑菌机理研究[D]. 成都: 西华大学, 2017.
Li K X.Study on extraction, bacteriostasis and bacteriostatic mechanism of tea polyphenols [D]. Chengdu: Xihua University, 2017.
[5] Dai W, Ruan C, Zhang Y, et al.Bioavailability enhancement of EGCG by structural modification and nano-delivery: a review[J]. Journal of Functional Foods, 2020, 65: 103732. doi: 10.1016/j.jff.2019.103732.
[6] 陈悦, 刘则渊, 陈劲, 等. 科学知识图谱的发展历程[J]. 科学学研究, 2008(3): 449-460.
Chen Y, Liu Z Y, Chen J, et al.The development of scientific knowledge atlas[J]. Studies in Science of Science, 2008(3): 449-460.
[7] 周煜杰, 贾夏, 赵永华, 等. 基于文献计量的土壤微生物海拔分布规律研究[J]. 生态与农村环境学报, 2021, 37(10): 1281-1291.
Zhou Y J, Jia X, Zhao Y H, et al.Review on soil microbial patterns along the elevation gradient based on the knowledge mapping analysis[J]. Journal of Ecology and Rural Environment, 2021, 37(10): 1281-1291.
[8] 张超, 文涛, 张媛, 等. 基于文献计量分析的镰刀菌枯萎病研究进展解析[J]. 土壤学报, 2020, 57(5): 1280-1291.
Zhang C, Wen T, Zhang Y, et al.Bibliometric-based analysis of advances in researches on Fusarium Wilt disease[J]. Acta Pedologica Sinica, 2020, 57(5): 1280-1291.
[9] 汪敏. 茶树病虫害检测及防治信息挖掘与可视化分析[D]. 合肥: 安徽农业大学, 2020.
Wang M.Tea tree diseases and insect pests detection and control information mining and visual analysis [D]. Hefei: Anhui Agricultural University, 2020.
[10] 陈磊. 我国健身气功研究的知识图谱分析[D]. 武汉: 武汉体育学院, 2020.
Chen L.The mapping knowledge analysis of health Qigong domain research in China [D]. Wuhan: Wuhan Sports University, 2020.
[11] 左小博, 孔俊豪, 杨秀芳,等. 茶多酚产业现状与发展展望[J]. 中国茶叶加工, 2019(4): 14-20.
Zuo X B, Kong J H, Yang X F, et al.Tea polyphenols industry status and development prospect[J]. China Tea Processing, 2019(4): 14-20.
[12] 雷雅婷, 胡涵, 王翠仙, 等. 世界茶叶贸易与发展趋势分析[J]. 现代农业科技, 2018(1): 284-286, 288.
Lei Y T, Hu H, Wang C X, et al.Analysis on trade and development trend of tea in the world[J]. Modern Agricultural Science and Technology, 2018(1): 284-286, 288.
[13] 堵茜, 朱海燕. 茶产品消费趋势问卷调查分析报告[J]. 茶叶通讯, 2020, 47(3): 521-525.
Du Q, Zhu H Y.Questionnaire analysis report on the consumption trend of tea products[J]. Journal of Tea Communication, 2020, 47(3): 521-525.
[14] 王亮, 谷康辉, 杨晨阳, 等. 亲水改性ZIF-8对聚酰胺纳滤膜性能的影响[J]. 天津工业大学学报, 2021, 40(4): 18-23.
Wang L, Gu K H, Yang C Y, et al.Effect of hydrophilic modified ZIF-8 on properties of polyamide nanofiltration membrane[J]. Journal of Tiangong University, 2021, 40(4): 18-23.
[15] Hu X, Wen J, Zhang H, et al.Can epicatechin gallate increase Cr(VI) adsorption and reduction on ZIF-8?[J]. Chemical Engineering Journal, 2020, 391: 123501. doi: 10.1016/j.cej.2019.123501.
[16] Zhang N, Jiang B, Zhang L, et al.Low-pressure electroneutral loose nanofiltration membranes with polyphenol-inspired coatings for effective dye/divalent salt separation[J]. Chemical Engineering Journal, 2019, 359: 1442-1452.
[17] Bu L, Bi C, Shi Z, et al.Significant enhancement on ferrous/persulfate oxidation with epigallocatechin-3-gallate: simultaneous chelating and reducing[J]. Chemical Engineering Journal, 2017, 321: 642-650.
[18] Tang S, Ma Q, Luo J, et al.The inhibition effect of tea polyphenols on soil nitrification is greater than denitrification in tea garden soil[J]. Science of The Total Environment, 2021, 778. doi: 10.1016/j.scitotenv.2021.146328.
[19] 杨海伦, 刘小香, 朱军莉, 等. 茶多酚的抗菌特性研究进展[J]. 食品工业科技, 2015, 36(21): 385-389.
Yang H L, Liu X X, Zhu J L, et al.Research progress in antibacterial properties of tea polyphenols[J]. Science and Technology of Food Industry, 2015, 36(21): 385-389.
[20] Naujokat C, Mckee D L.The "Big Five" phytochemicals targeting cancer stem cells: curcumin, EGCG, sulforaphane, resveratrol and genistein[J]. Current Medicinal Chemistry, 2021, 28(22): 4321-4342.
[21] Fujiki H, Suganuma M, Okabe S, et al.Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1[J]. Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis, 2001, 480(s1): 299-304.
[22] 黄美蓉. EGCG纳米粒的制备及其体外抗肿瘤活性研究[D]. 杭州: 浙江工商大学, 2016.
Huang M R.Prepar action of EGCG-nanoparticles and its antitumor activities in vitro [D]. Hangzhou: Zhejiang Gongshang University, 2016.
[23] Singha B, Shankarb S, Srivastavaa R.Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical Biochemical applications[J]. Journal of Green Building, 2011, 82(12):1807-1821.
[24] Su Y L, Leung L K, Huang Y, et al.Stability of tea theaflavins and catechins[J]. Food Chemistry, 2003, 83(2): 189-195.
[25] Sang S, Lee M J, Hou Z, et al.Stability of tea polyphenol (-)-epigallocatechin-3-gallate and formation of dimers and epimers under common experimental conditions[J]. Journal of Agricultural and Food Chemistry, 2005, 53(24): 9478-9484.
[26] 张杨波, 饶甜甜, 刘仲华. 茶多酚的抗癌作用机制及EGCG纳米载体技术研究进展[J]. 食品工业科技, 2019, 40(16): 343-348.
Zhang Y B, Rao T T, Liu Z H.Research progress on the anticancer mechanism of tea polyphenol and EGCG nanocarrier technology[J]. Science and Technology of Food Industry, 2019, 40(16): 343-348.
[27] Mereles D, Hunstein W.Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?[J]. International Journal of Molecular Sciences, 2011, 12(9): 5592-5603.
[28] Singh B N, Shankar S, Srivastava R K.Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications[J]. Biochemical Pharmacology, 2011, 82(12): 1807-1821.
[29] Kim H, Quon M J, Kim J.New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate[J]. Redox Biology, 2014, 2: 187-195.
[30] Steinmann J, Buer J, Pietschmann T, et al.Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea[J]. British Journal of Pharmacology, 2013, 168(5): 1059-1073.
[31] Du G, Zhang Z, Wen X, et al.Epigallocatechin gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea[J]. Nutrients, 2012, 4(11): 1679-1691.
[32] Lecumberri E, Dupertuis Y M, Miralbell R, et al.Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy[J]. Clinical Nutrition, 2013, 32(6): 894-903.
[33] Li F, Qasim S, Li D, et al.Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator[J]. Seminars in Cancer Biology, 2021, 42. doi: 10.1016/j.semcancer.2020.11.018.
[34] Othman A I, El-Sawi M R, El-Missiry M A, et al. Epigallocatechin-3-gallate protects against diabetic cardiomyopathy through modulating the cardiometabolic risk factors, oxidative stress, inflammation, cell death and fibrosis in streptozotocin-nicotinamide-induced diabetic rats[J]. Biomedicine & Pharmacotherapy, 2017, 94: 362-373.
[35] Ding J, Yao J, Xue J, et al.Tumor-homing cell-penetrating peptide linked to colloidal mesoporous silica encapsulated (-)-epigallocatechin-3-gallate as drug delivery system for breast cancer therapy in vivo[J]. ACS Appl Mater Interfaces, 2015, 7(32): 18145-18155.
[36] Lambert J D, Kennett M J, Sang S, et al.Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice[J]. Food and Chemical Toxicology, 2010, 48(1): 409-416.
[37] Kanadzu M, Lu Y, Morimoto K.Dual function of (-)-epigallocatechin gallate (EGCG) in healthy human lymphocytes[J]. Cancer Letters, 2006, 241(2): 250-255.

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract

参考文献