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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (3): 250-260.doi: 10.13305/j.cnki.jts.2016.03.004

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Intervention Effects of Fuzhuan Brick Tea Water Extract on Glucose Metabolism Disorder in a Mouse Model of Type Ⅱ Diabetes Mellitus

HUANG Song1,2, LIU Zhonghua1,2,3, HUANG Jian′an1,3, YANG Heng1,2, LI Qin1,2,3,*   

  1. 1. Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China;
    2. National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Changsha 410128, China;
    3. Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China
  • Received:2015-11-17 Online:2016-06-15 Published:2019-08-23

Abstract: In this study, streptozotocin (STZ) combined with a high-fat and high-sugar diet was used to generate a mouse model of type 2 diabetes mellitus. The aim of this study was to investigate the hypoglycemic effects of Fuzhuan brick tea water extract (FTEs) on T2DM-Mice. Results showed that FTEs could obviously alleviate weight loss, polyuria, polydipsia, and polyphagia, reduce fasting plasma glucose, increase sugar tolerance, enhance insulin concentrations and insulin sensitivity and decrease insulin resistance in the diabetic mice. Moreover, RT-qPCR analysis showed that FTEs promoted glucose transport and liver lipid metabolism, and improved the glucose metabolism in the diabetic mice by increasing the expression of PPAR-α, GLUT2, and GLUT4. Therefore, it can be concluded that FTEs could significantly improve glucose metabolism disorder symptom of T2DM-Mice by a dose-dependent manner.

Key words: Fuzhuan brick tea water extract, type 2 diabetes mellitus, hypoglycemic, glucose metabolism

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