Research Progress on the Antagonistic Effects of Tea Polyphenols Against Human Oxidative Stress Induced by Environmental Pollutants

QIAN Yiyue; ZHANG Xiangchun; CHEN Hongping; FU Zhouping; YU Jizhong; ZHENG Qinqin

doi:10.13305/j.cnki.jts.2026.05.003

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Journal of Tea Science ›› 2026, Vol. 46 ›› Issue (5) : 761-774. DOI: 10.13305/j.cnki.jts.2026.05.003

Review

Research Progress on the Antagonistic Effects of Tea Polyphenols Against Human Oxidative Stress Induced by Environmental Pollutants

QIAN Yiyue¹, ZHANG Xiangchun², CHEN Hongping², FU Zhouping^3,*, YU Jizhong⁴, ZHENG Qinqin^2,*

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Abstract

Environmental pollutants are important exogenous factors inducing oxidative stress in humans. Fine particulate matter, heavy metals and other pollutants enter the human body and trigger oxidative stress by inducing excessive generation of reactive oxygen species. This impairs mitochondrial function and activates inflammatory signaling pathways, which subsequently contribute to the development of various chronic diseases. Tea polyphenols, as the primary antioxidant components in tea, can directly scavenge free radicals, activate the Nrf2/ARE signaling pathway, inhibit pro-oxidant enzyme activity, protect mitochondria and block the inflammation-oxidative stress vicious cycle, thereby alleviating oxidative damage. This paper reviewed the classification of common environmental pollutants and the mechanisms by which they induce oxidative stress in humans, systematically analyzed the pathways through which tea polyphenols mitigate oxidative stress and their protective effects at the cellular, organ and systemic levels, and elucidated the application value of tea consumption and tea polyphenol-related products in counteracting health risks associated with environmental pollution.

Key words

environmental pollutants / human oxidative stress / tea polyphenols / antioxidant effect / antagonistic application

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QIAN Yiyue, ZHANG Xiangchun, CHEN Hongping, FU Zhouping, YU Jizhong, ZHENG Qinqin. Research Progress on the Antagonistic Effects of Tea Polyphenols Against Human Oxidative Stress Induced by Environmental Pollutants[J]. Journal of Tea Science. 2026, 46(5): 761-774 https://doi.org/10.13305/j.cnki.jts.2026.05.003

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