The effects of different dosages of L-theanine on SPF grade Balb/KM male mice under heat treatment, including feed intake, weight, organs index, histopathological features of jejunum, activities of serum alanine aminotranferease (ALT) and aspartate aminotransferase (AST), contents of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interferon-γ (IFN-γ) in serum, content of liver homogenate malondialdehyde (MDA), activities of liver homogenate superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and histopathological features of liver tissue were studied. Results showed that pretreatment with different dosages of L-theanine increased the feed intake and body weight of the mice, enhanced the activities of liver homogenate SOD, CAT, GSH-Px, decreased the index of liver and spleen, damages in the jejunum, activities of serum ALT, AST, contents of TNF-α, IL-6 and IFN-γ in serum, content of liver homogenate MDA and attenuated the damages of liver by heat treatment. The best attenuating effect of L-theanine on damages was under middle dosage treatment. It suggests that L-theanine mainly improves the absorptive capacity, reduces the expressions of inflammatory cytokines and oxidative damage in mice, which finally attenuate the tissue and oxidative damages caused by heat stress.
Key words
heat stress /
oxidative stress /
tissue damage /
L-theanine
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