Alleviative Effects of Aged Liupao Tea on Lipid Metabolism and Liver Injury in Hyperlipidemic Mice

WU Wenliang; LIU Zhonghua; LIN Yong; HUANG Jian&#x02032;an; ZUO Gaolong; TENG Cuiqin; LONG Zhirong; QIU Ruijin; CAO Zhonghuan

doi:10.13305/j.cnki.jts.2018.04.012

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Journal of Tea Science ›› 2018, Vol. 38 ›› Issue (4) : 430-438. DOI: 10.13305/j.cnki.jts.2018.04.012

Alleviative Effects of Aged Liupao Tea on Lipid Metabolism and Liver Injury in Hyperlipidemic Mice

WU Wenliang^1,2,3,4, LIU Zhonghua^1,2,3,*, LIN Yong^1,2,3,*, HUANG Jian′an^1,2,3, ZUO Gaolong^1,2, TENG Cuiqin⁵, LONG Zhirong⁶, QIU Ruijin⁵, CAO Zhonghuan⁵

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Abstract

To investigate the alleviative effects of aged Liupao tea on lipid metabolism and liver injury in hyperlipidemic mice, the changes of main chemical substances in Liupao tea of different storage ages were analyzed. The hyperlipidemia model mice were established by feeding a high fat and sugar diet, and Liupao tea groups were given daily oral administration of water extract of selected aged Liupao tea. The changes of related physiological and biochemical indexes and tissue morphology in mice were observed. The results showed that Liupao tea samples stored for 15 years were selected as the representative of the aged Liupao tea, which was used in subsequent experiments. Compared with the hyperlipidemia model group, aged Liupao tea especially medium or high dose groups could significantly decrease the contents of TC, TG, and LDL-C levels, increase the content of HDL-C, suppress the activities of ALT and AST in the serum, and moderate liver oxidative stress,. Pathological sections of liver and adipose tissue showed that aged Liupao tea could reduce the formation of lipid droplets in liver cells and inhibit the enlargement of fat cells in a dose dependent manner. In conclusion, aged Liupao tea of normal dose could effectively improve lipid metabolism disorder and liver injury in mice induced by high fat and sugar diet.

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aged Liupao tea / alleviative effect / hyperlipidemia / lipid metabolism / liver injury

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WU Wenliang, LIU Zhonghua, LIN Yong, HUANG Jian′an, ZUO Gaolong, TENG Cuiqin, LONG Zhirong, QIU Ruijin, CAO Zhonghuan. Alleviative Effects of Aged Liupao Tea on Lipid Metabolism and Liver Injury in Hyperlipidemic Mice[J]. Journal of Tea Science. 2018, 38(4): 430-438 https://doi.org/10.13305/j.cnki.jts.2018.04.012

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