In order to verify the security of the formulating Puer tea products, the acute toxicity experiments were carried out on mice. The standard Puer tea extracts were taken as the control. LD₅₀ of the Pure tea, Ganodorma lucidum’s Puer tea, American ginseng’s Puer tea, Phyllanthus emblica’s Puer tea and the Fagopyrum tartaricum’s Puer tea were determined as 10.32 g/kg, 10.02 g/kg, 10.02 g/kg, 10.96 g/kg, 10.32 g/kg individually. The formulating Puer tea products and the Pure tea showed no significant difference in the aspects of the physical and chemistry comparison tests. The acute toxicity experimental results indicated that these four formulating puer tea products belong to the actual non-toxic grade according to the food toxicology standard.