To establish the hyperlipidmia rat models by feeding high lipid diet, then the herb, tea and oolong herb tea were irrigated into stomach separately for 35 days in succession, the level on the activity of ALT, AST enzyme and the level of cholesterols of TCHO, TG, HDL-C, LDL-C, as well the contents of NO and ET-1 in rat blood measured were measured. Meanwhile, the general conditions and histopathological changes in tissues of liver and kidney were observed to explore the influence of Oolong herb tea on the serum lipid level and the preventive effect on vein endothelium cells in experimental hyperlipidemia rats investigated. Results showed that compared the blood levels of TCHO, TC, LDL-C, TCHO and the ET-1 content were reduced significantly in treatment group while HDL-C and NO increased(P<0.05, P<0.01) compared with the control group. The effect of Oolong herb tea was more remarkable than that of herb and tea treatment. It is concluded that the herb, tea and Oolong herb tea are able to regulate the level of serum lipid effectively prevent hyperlipidemia and have a protective effect of vein endothelium cells. It is showed that the synergistic effect between herb and tea and improve the efficacy in Oolong herb tea.