The water extract of Enshi Se-enriching Tengcha(ESTC) on the animal safety was investigated according to the Standard of Health Food Test and Assess. Acute toxicity test on mice showed that LD50 was greater than 30βg/kg.bw. Three genetic tests showed negative results. 90 days feeding test showed that the outer appearance, behavior, weights, organ coefficients, the indexes of hematology and biochemistry in rats have no significant difference comparing with the control group. Significant pathological changes of inherent organs were not discovered. All results showed that ESTC was safet for rats.
CHEN Yu-qiong
,
XIANG Ban-gui
,
NI De-jiang
,
WU Mou-cheng
,
ZHOU Ji-rong
,
YU Zhi
,
ZENG Wei-chao
. Study on the Toxicology of Se-Enriching Ampelopsis Grossedentata from Enshi[J]. Journal of Tea Science, 2005
, 25(4)
: 295
-299
.
DOI: 10.13305/j.cnki.jts.2005.04.010
[1] 全国中草药汇编编写组. 全国中草药汇编(下册)(M). 北京: 人民卫生出版社, 1997.
[2] 保健食品检验与评价技术规范, 2003.
[3] 孙敬方. 动物实验方法学(M). 北京: 人民卫生出版社, 2001.
[4] 食品安全性毒理学评价程序和方法, GB15193—94.
[5] 李焕德. 临床药学(M). 北京: 人民卫生出版社, 2003.
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