茶多酚拮抗环境污染物诱导人体氧化应激研究进展

钱益跃; 张相春; 陈红平; 付周平; 余继忠; 郑芹芹

doi:10.13305/j.cnki.jts.2026.05.003

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茶叶科学 ›› 2026, Vol. 46 ›› Issue (5) : 761-774. DOI: 10.13305/j.cnki.jts.2026.05.003

综述

茶多酚拮抗环境污染物诱导人体氧化应激研究进展

钱益跃¹, 张相春², 陈红平², 付周平^3,*, 余继忠⁴, 郑芹芹^2,*

作者信息 +

Research Progress on the Antagonistic Effects of Tea Polyphenols Against Human Oxidative Stress Induced by Environmental Pollutants

QIAN Yiyue¹, ZHANG Xiangchun², CHEN Hongping², FU Zhouping^3,*, YU Jizhong⁴, ZHENG Qinqin^2,*

Author information +

文章历史 +

摘要

环境污染物是诱导人体氧化应激的重要外源因素。大气细颗粒物、重金属等进入人体后,通过诱导活性氧过度生成、损伤线粒体功能及激活炎症信号通路,引发氧化应激,进而诱发多种慢性疾病。茶多酚作为茶叶中主要的抗氧化活性成分,能够直接清除自由基、激活Nrf2/ARE信号通路、抑制促氧化酶活性、保护线粒体并阻断炎症-氧化应激恶性循环,从而减轻氧化损伤。本文综述了常见环境污染物的分类及其诱导人体氧化应激的机制,系统分析了茶多酚缓解氧化应激的作用路径及其在细胞、器官及系统水平的保护作用证据,并阐明了饮茶及茶多酚相关产品在抵御环境污染健康风险中的应用价值。

Abstract

Environmental pollutants are important exogenous factors inducing oxidative stress in humans. Fine particulate matter, heavy metals and other pollutants enter the human body and trigger oxidative stress by inducing excessive generation of reactive oxygen species. This impairs mitochondrial function and activates inflammatory signaling pathways, which subsequently contribute to the development of various chronic diseases. Tea polyphenols, as the primary antioxidant components in tea, can directly scavenge free radicals, activate the Nrf2/ARE signaling pathway, inhibit pro-oxidant enzyme activity, protect mitochondria and block the inflammation-oxidative stress vicious cycle, thereby alleviating oxidative damage. This paper reviewed the classification of common environmental pollutants and the mechanisms by which they induce oxidative stress in humans, systematically analyzed the pathways through which tea polyphenols mitigate oxidative stress and their protective effects at the cellular, organ and systemic levels, and elucidated the application value of tea consumption and tea polyphenol-related products in counteracting health risks associated with environmental pollution.

导出引用

钱益跃, 张相春, 陈红平, 付周平, 余继忠, 郑芹芹. 茶多酚拮抗环境污染物诱导人体氧化应激研究进展[J]. 茶叶科学. 2026, 46(5): 761-774 https://doi.org/10.13305/j.cnki.jts.2026.05.003

QIAN Yiyue, ZHANG Xiangchun, CHEN Hongping, FU Zhouping, YU Jizhong, ZHENG Qinqin. Research Progress on the Antagonistic Effects of Tea Polyphenols Against Human Oxidative Stress Induced by Environmental Pollutants[J]. Journal of Tea Science. 2026, 46(5): 761-774 https://doi.org/10.13305/j.cnki.jts.2026.05.003

中图分类号： S571.1 TS272.5

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