探讨了乌龙茶多糖（OTPS）对高脂模型小鼠血脂的调节作用及机制。采用高脂饲料饲喂法建立高脂血症小鼠模型,通过不同剂量OTPS灌胃6周后,测定了小鼠的体重、胸腺重量、脾脏重量、肝脏重量、血脂水平、血清和肝脏中丙二醛（MDA）和超氧化物歧化酶（SOD）的含量,以及观察了肝脏的病理变化。结果表明,与高脂模型对照组比较,OTPS剂量组血清总胆固醇（TC）和低密度脂蛋白（LDL-C）、血清和肝脏MDA、肝脏指数显示不同程度的降低,胸腺指数、脾指数、血清和肝脏SOD活力则有所上升,肝脏病变有一定程度的减轻,说明乌龙茶多糖具有一定的调节血脂、提高机体免疫力及抗氧化的作用。
The adjusting effects of Oolong tea polysaccharide (OTPS) on serum lipid in hyperlipoidemia mice and its mechanism were investigated. The hyperlipidmia mice model was established by feeding high lipid diet, and different groups were taken OTPS by intragastric administration for 6 weeks. In present investigation, body weight, thymus weight, spleen weight, liver weight, blood lipid levels, malondialdehyde (MDA) and liver superoxide dismutase (SOD) activities of serum and liver were measured, as well the histopathological changes in tissues of liver were observed. The results showed that the contents of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), serum and liver MDA, liver index were lower in comparison with the high hyperlipoidemia model group, while thymus index, spleen index, serum and liver SOD activities were somewhat higher, and the liver lesions were restored in some degree. It is indicated that OTPS showed a positive effect on adjusting the serum lipid, improving immunity of body and antioxidation.
[1] 徐仲溪, 王坤波. 茶多糖化学及生物活性的研究[J]. 茶叶科学, 2004, 24(2): 75-81.
[2] 王丁刚, 王淑如. 茶叶多糖的分离、纯化、分析及降血脂作用[J]. 中国药科大学学报, 1991, 22(4): 225-228.
[3] 汪东风, 谢晓凤, 王泽农, 等. 粗老茶中的多糖含量及其保健作用[J]. 茶叶科学, 1994, 14(1): 73-74.
[4] 周杰, 丁建平, 王泽农, 等. 茶多糖对小鼠血糖、血脂和免疫功能的影响[J]. 茶叶科学, 1997, 17(1): 75-79.
[5] 侯仰锋, 汪东风, 周小玲, 等. 茶多糖对高脂血症大鼠血脂及肝脏中微量元素的调节作用[J]. 营养学报, 2008, 30(3): 269-272.
[6] 吴文华, 吴文俊. 普洱茶多糖降血脂功能的量效关系. 福建茶叶, 2006(2): 42-43.
[7] 赵水平. 大幅度降低胆固醇能更有效地防治冠心病[J]. 中华医学信息导报, 2006, 21(12): 22.
[8] Napoli C, Lerman L O.Involvement of oxidation-sensitive mechanisms in the cardiovascular effects of hypercholesterolemia[J]. Mayo Clin Proc, 2001, 76(6): 619-631.
[9] Rodriguez-Porcel M, Lerman A, Best P J M, et al. Hypercholesterolemia impairs myocardial perfusion and permeability: role of oxidative stress and endogenous scavenging activity[J]. J Am Coll Cardiol, 2001, 37(2): 608-615.
[10] Stokes K Y, Cooper D, Tailor A, et al. Hypercholesterolemia promotes inflammation and microvascular dysfunction: Role of nitric oxide and superoxide[J]. Free Radic Biol Med, 2002, 33(8): 1026-1036.
[11] 倪淑华, 李秀花, 高竹琦, 等. 酸化豆粉对大鼠降血脂和抗氧化作用的影响[J]. 中国公共卫生, 2005, 21(8): 965-966.
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