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茶叶科学 ›› 2011, Vol. 31 ›› Issue (5): 399-404.doi: 10.13305/j.cnki.jts.2011.05.005

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乌龙茶多糖调节血脂作用及其机制研究

张芸1,2, 倪德江3, 陈永波3, 黄海波3, 刘思思3, 谢笔钧1*   

  1. 1. 华中农业大学食品科技学院,湖北 武汉 430070;
    2. 湖北经济学院旅游与酒店管理学院,湖北 武汉 430205;
    3. 华中农业大学园艺林学学院园艺植物生物学教育部重点实验室,湖北 武汉 430070
  • 收稿日期:2011-04-26 修回日期:2011-06-02 出版日期:2011-10-15 发布日期:2019-09-09
  • 作者简介:张芸(1979— ),女,湖北广水人,博士研究生,主要从事天然产物化学研究。

Effect of Oolong Tea Polysaccharide in Adjusting Serum Lipid and Its Mechanism

ZHANG Yun1,2, NI De-jiang3, CHEN Yong-bo3, HUANG Hai-bo3, LIU Si-si3, XIE Bi-jun1*   

  1. 1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China;
    2. College of Tourism and Hotel Management, Hubei University of Economics, Wuhan 430205, China;
    3. Key Lab of Horticultural Plant Biology of Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, China
  • Received:2011-04-26 Revised:2011-06-02 Online:2011-10-15 Published:2019-09-09

摘要: 探讨了乌龙茶多糖(OTPS)对高脂模型小鼠血脂的调节作用及机制。采用高脂饲料饲喂法建立高脂血症小鼠模型,通过不同剂量OTPS灌胃6周后,测定了小鼠的体重、胸腺重量、脾脏重量、肝脏重量、血脂水平、血清和肝脏中丙二醛(MDA)和超氧化物歧化酶(SOD)的含量,以及观察了肝脏的病理变化。结果表明,与高脂模型对照组比较,OTPS剂量组血清总胆固醇(TC)和低密度脂蛋白(LDL-C)、血清和肝脏MDA、肝脏指数显示不同程度的降低,胸腺指数、脾指数、血清和肝脏SOD活力则有所上升,肝脏病变有一定程度的减轻,说明乌龙茶多糖具有一定的调节血脂、提高机体免疫力及抗氧化的作用。

关键词: 乌龙茶多糖, 血脂, 抗氧化

Abstract: The adjusting effects of Oolong tea polysaccharide (OTPS) on serum lipid in hyperlipoidemia mice and its mechanism were investigated. The hyperlipidmia mice model was established by feeding high lipid diet, and different groups were taken OTPS by intragastric administration for 6 weeks. In present investigation, body weight, thymus weight, spleen weight, liver weight, blood lipid levels, malondialdehyde (MDA) and liver superoxide dismutase (SOD) activities of serum and liver were measured, as well the histopathological changes in tissues of liver were observed. The results showed that the contents of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), serum and liver MDA, liver index were lower in comparison with the high hyperlipoidemia model group, while thymus index, spleen index, serum and liver SOD activities were somewhat higher, and the liver lesions were restored in some degree. It is indicated that OTPS showed a positive effect on adjusting the serum lipid, improving immunity of body and antioxidation.

Key words: Oolong tea polysaccharide, serum lipid, antioxidation

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