山茶属植物之山茶皂苷及其药理活性研究进展

doi:10.13305/j.cnki.jts.2011.05.016

茶叶科学 ›› 2011, Vol. 31 ›› Issue (5): 391-398.doi: 10.13305/j.cnki.jts.2011.05.016

山茶属植物之山茶皂苷及其药理活性研究进展

夏晓萍¹, 郑彩虹^1*, 俸春红², 夏春华²

1. 浙江大学医学院附属妇产科医院,浙江杭州 310006;
2. 中国农业科学院茶叶研究所,浙江杭州 310008

收稿日期:2011-01-11 修回日期:2011-04-11 出版日期:2011-10-15 发布日期:2019-09-09
作者简介:夏晓萍（1974— ）,女,浙江杭州人,主要从事临床药学及天然产物药学的研究。
基金资助:
浙江省中医药科技计划资助项目（2008CA066）

Progress in Study on the Chemical Structure and Pharmacological Activities of Triterpene Saponins from Tea Plant (Theaceae)

XIA Xiao-ping¹, ZHENG Cai-hong^1*, FENG Chun-hong², XIA Chun-hua²

1. Women,s hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;
2. Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China

Received:2011-01-11 Revised:2011-04-11 Online:2011-10-15 Published:2019-09-09

摘要/Abstract

摘要： 近年来从山茶属植物中陆续分离得到50余种山茶皂苷。本文对有代表性的文献进行了分析归纳,综述了山茶属植物之山茶皂苷的化学结构和药理活性研究进展,为进一步研究山茶皂苷的生物学和药物学特性,提供了理论基础。

关键词: 山茶属, 三萜皂苷, 化学结构, 药理活性

Abstract: More than 50 new triterpene saponins from tea plant (Theaceae) were reported in last two decades. For the purpose of introducing the advance on the chemical structure and pharmacological activities, the representative literature were analysized.

Key words: Theaceae, triterpene saponins, chemical structure, pharmacological activities

中图分类号:

Q946.83

夏晓萍, 郑彩虹, 俸春红, 夏春华. 山茶属植物之山茶皂苷及其药理活性研究进展[J]. 茶叶科学, 2011, 31(5): 391-398. doi: 10.13305/j.cnki.jts.2011.05.016.

XIA Xiao-ping, ZHENG Cai-hong, FENG Chun-hong, XIA Chun-hua. Progress in Study on the Chemical Structure and Pharmacological Activities of Triterpene Saponins from Tea Plant (Theaceae)[J]. Journal of Tea Science, 2011, 31(5): 391-398. doi: 10.13305/j.cnki.jts.2011.05.016.

参考文献

[1] 青山新次郎. 茶(Thea sinensin L.)の實中のサボニンに就て[J]. 薬学雜誌, 1931, 51(5): 591.
[2] 石館守三, 上田阳. 茶実中のサポニンの研究第1报[J]. 薬学雜誌, 1952, 72(11): 1523-1528.
[3] 谭新东, 肖纯. 茶树各部分茶皂素含量的测定和比较分析[J]. 茶业通报, 2001, 23(1): 25-27.
[4] 王路, 夏晓萍. 茶皂素HLB值的结构分析[J]. 天然产物研究与开发, 1990, 2(2): 33-36.
[5] Morikawa T, Li N, Nagatomo A, et al. Triterpene saponins with gastroprotective effects from tea seed (the seeds of camellia sinensis)[J]. Journal of Natural Products, 2006, 69(2): 185-190.
[6] Yoshikawa M, Morikawa T, Nakamura S, et al. Bioactive saponins and glycosides. ⅩⅩⅤ. Acylated Oleanane-type triterpene saponins from the seeds of tea plant(camellia sinensis)[J]. Chemical and Pharmaceutical Bulletin, 2007, 55(1): 57-63.
[7] Kitagawa I, Hori K, Motozawa T, et al. Strutures of new acylated oleanene-type triterpene oligoglycosides, theasaponins E₁ and E₂ from the seeds of tea plant, camellia sinensis L. O. KUNTZE[J]. Chemical and Pharmaceutical Bulletin, 1998, 46(12): 1901-1906.
[8] Yoshikawa M, Morikawa T, Li N, et al. Bioactive saponins and glycosides.ⅩⅩⅢ. Triterpene saponins with gastroprotective effect from the seeds of camellia sinensis-theasaponins E₃ E₄ E₅ E₆ and E₇[J]. Chemical and Pharmaceutical Bulletin, 2005, 53(12): 1559-1564.
[9] Murakami T, Nakamura J, Matsuda H, et al. Bioactive saponins and glycosides.ⅩⅤ. constituents with gastroprotective effect from the seeds of tea plant, camellia sinensis L. var. assamica pierre, cultivated in srilanka: structures of assamsaponins A,B,C,D and E[J]. Chemical and Pharmaceutical Bulletin, 1999, 47(12): 1759-1764.
[10] Murakami T, Nakamura J, Kageura T, et al. Bioactive saponins and glycosides.ⅩⅦ. Inhibitory effect on gastric emptying and accelerating effect on gastrointestinal transit of tea saponins: structures of assamsaponins F,G,H,I and J from the seeds and leaves of structures of assamsaponins F,G,H,I and J from the seeds and leaves of the tea plant[J]. Chemical and Pharmaceutical Bulletin, 2000, 48(11): 1720-1725.
[11] Yoshikawa M, Murakami T, Yoshizumi S, et al. Bioactive saponins and glycosides.Ⅴ. Acylated polyhydroxyolean-12-ene triterpene oligoglycosides, camelliasaponinsA₁ A₂ B₁ B₂ C₁ and C₂,from the seeds of camellia japonica L.: Structures and Inhibitory activity on alcohol absorption[J]. Chemical and Pharmaceutical Bulletin, 1996, 44(10): 1899-1907.
[12] Mitane S Y, Uemura T.A new glucuronided saponin from tea leaves[J]. Bioscience Biotechnology Biochemistry, 1994, 58(11): 2036-2040.
[13] Kobayashi K, Teruya T, Suenaga K, et al. Isotheasaponins B-B from camellia sinensis var. sinensis tea leaves[J]. Phytochemistry, 2006,67(13):1385-1389.
[14] Morikawa T, Nakamura S, Kato Y, et al. Bioactive saponins and glycosides.ⅩⅩⅧ. New triterpene saponins,Foliatheasaponins Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ from Tencha(the leaves of camellia sinensins)[J]. Chemical and Pharmaceutical Bulletin, 2007, 55(2): 293-298.
[15] Lu Y, Umeda T, Yagi A, et al. Triterpenoid saponins from the roots of tea plant (camellia sinensis var. assamica)[J]. Phytochemistry, 2000, 53(8): 941-946.
[16] Yoshikawa M, Morikawa T, Yamamoto K, et al. Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (camellia sinensis)[J]. Journal of Natural Products, 2005, 68(9): 1360-1365.
[17] Yoshikawa M, Nakamura S, kato Y, et al. Medicinal Flowers.ⅩⅣ. New acylated Oleanane-type Triterpene Oligoglycosides with Antiallergic activity from flower buds of Chinese Tea Plant (camellia sinese)[J]. Chemical and pharmaceutical Bulletin, 2007, 55(4): 598-605.
[18] Potter D A, Redmond C T, Meepagala K M, et al. Managing earthworm casts(Oligochaeta: Lumbricidae) in turfgrass using a natural byproduct of tea oil(Camellia sp.) manufacture[J]. Pest Management Science, 2010, 66(4): 439-446.
[19] 提坂裕子, 植村照美, 铃木裕子, 等. 茶葉サポニの抗菌作用ぴ抗炎作用[J]. 薬学雜誌, 1996, 116(3): 238-243.
[20] 叶红, 夏晓萍. 油茶皂苷对念珠菌体外抗菌作用研究(待发表).
[21] Chattopadhyay P, Besra S E, Gomes A, et al. Anti-inflammatory activity of tea (camellia sinensis) root extract[J]. Life Sciences, 2004, 74(15): 1839-1849.
[22] Akagi M, Fukuishi N, Kan T, et al. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis)[J]. Biological and Pharmmaceutical Bulletin, 1997, 20(5): 565-567.
[23] Yoshikawa M, Wang T, Sugimoto S, et al. Functional saponins in tea flower (Flower buds of camellia sinensis): Gastroprotective and Hypoglycemic effects of floratheasaponins and qualitative and quantitative analysis using HPLC[J]. YAKUGAKU ZASSHI, 2008, 128(1): 141-145.
[24] Ghosh P, Besra S E, Tripathi G, et al. Cytotoxic and apoptogenic effect of tea (Camellia sinensis var.assamica) root extract (TRE) and two of its steroidal saponins TS₁ and TS₂ on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients[J]. Leukemia Research, 2006, 30(4): 459-468.

山茶属植物之山茶皂苷及其药理活性研究进展

Progress in Study on the Chemical Structure and Pharmacological Activities of Triterpene Saponins from Tea Plant (Theaceae)

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