Study on Antitumor and Immune Regulation Activities of Anjibaicha Polysaccharide

XIA Dao-zong; ZHANG Yuan-jun; NI Da-mei; JU Meng-ting

doi:10.13305/j.cnki.jts.2013.01.008

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Journal of Tea Science ›› 2013, Vol. 33 ›› Issue (1) : 40-44. DOI: 10.13305/j.cnki.jts.2013.01.008

Study on Antitumor and Immune Regulation Activities of Anjibaicha Polysaccharide

XIA Dao-zong, ZHANG Yuan-jun, NI Da-mei, JU Meng-ting

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Abstract

The antitumor activity of anjibaicha polysaccharide in vitro by MTT method was investigated by the authors. For the purpose of investigating the antitumor and immune regulation functions of anjibaicha polysaccharide in vivo, to establish the transplant tumor model of mice, and determine the inhibition rate on tumor cells growth and peritoneal macrophage phagocytic function of tumor-burdened mice by anjibaicha polysaccharide. The results showed that the sarcoma-180 growth could be significant inhibited by anjibaicha polysaccharide in vitro and showed dose-dependent relation ship. The test in vivo showed that anjibaicha polysaccharide has significant inhibitory effects on sarcoma-180 and ascitic hepatoma H₂₂ growth in tumor-burdened mice (P<0.05). In addition, anjibaicha polysaccharide could increase thymus and spleen indexs in mice with sarcoma-180 and ascitic hepatoma H₂₂ cells. Moreover, anjibaicha polysaccharide could significantly increase the peritoneal macrophage phagocytic function in sarcoma-180-burdened mice (P<0.05).

Key words

anjibaicha polysaccharide / antitumor / immune regulation / peritoneal macrophage / phagocytic function

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XIA Dao-zong, ZHANG Yuan-jun, NI Da-mei, JU Meng-ting. Study on Antitumor and Immune Regulation Activities of Anjibaicha Polysaccharide[J]. Journal of Tea Science. 2013, 33(1): 40-44 https://doi.org/10.13305/j.cnki.jts.2013.01.008

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