The effect of EGCG on blood anticoagulation of mice was evaluated in this investigation. Results showed that EGCG with doses of 0.25g/(kg·d), 0.5g/(kg·d) and 1.0g/(kg·d)could significantly prolong bleeding time of mice tail and activated the partial thromboplastin time compared with control group, effectively depress fibrinogen level, while EGCG nearly has no impact on mice prothrombin time. EGCG with doses of 0.5g/(kg·d) and 1.0g/(kg·d) could effectively prolong coagulation time compared with control group. It is calculated that EGCG could inhibit the intrinsic coagulation pathway and prolong the blood coagulation time. EGCG showed obvious blood anticoagulation effect.
WANG Xian-bo
,
CHENG Hao
,
ZHAO Yun
,
HUANG Hai-tao
. Study on the EGCG from Tea on the Blood Anticoagulation Effect of Mice[J]. Journal of Tea Science, 2011
, 31(6)
: 532
-536
.
DOI: 10.13305/j.cnki.jts.2011.06.009
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