The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

LI Shigang; ZHENG Qianqian; HE Jiangang; XIAO Changyi; LIU Wei; WANG Hui; LIU Jincheng

doi:10.13305/j.cnki.jts.2016.03.003

Journal of Tea Science >

2016 , Vol. 36 >Issue 3: 245 - 249

DOI: https://doi.org/10.13305/j.cnki.jts.2016.03.003

The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

LI Shigang ,
ZHENG Qianqian ,
HE Jiangang ,
XIAO Changyi ,
LIU Wei ,
WANG Hui ,
LIU Jincheng

Expand

1. Long Cheng Chuan Qingzhuan Tea Research Institute of Hubei Province, Yichang 443002, China;
2. Medical College of China Three Gorges University, Yichang 443002, China;
3. Biotechnology and Pharmaceutical Engineering College of China Three Gorges University, Yichang 443002, China

Received date: 2015-12-21

Online published: 2019-08-23

Fold

Abstract

The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels.

Key words： Hubei Qingzhuan tea; IBS-D; visceral sensitivity; colon tissue; inflammatory cytokines

Cite this article

LI Shigang , ZHENG Qianqian , HE Jiangang , XIAO Changyi , LIU Wei , WANG Hui , LIU Jincheng . The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model[J]. Journal of Tea Science, 2016 , 36(3) : 245 -249 . DOI: 10.13305/j.cnki.jts.2016.03.003

References

[1] Thompson W, Longstreth G, Drossman D, et al. Functional bowel disorders and functional abdominal pain [J]. Gut, 1999, 45(3): II43-II47.
[2] Nakanishi M, Menoret A, Tanaka T, et al.Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity[J]. Cancer Prevention Research, 2011, 4(8): 1198-1208.
[3] Veek P P J V D, Marlies V D B, Kroon Y E D, et al. Role of tumor necrosis factor-α and interleukin-10 gene polymorphisms in irritable bowel syndrome[J]. American Journal of Gastroenterology, 2005, 100(11): 2510-2516.
[4] 郭朝书, 王承党. 肥大细胞及类胰蛋白酶在肠易激综合征内脏敏感性中的作用[J]. 国际消化病杂志, 2010, 30(1): 4-5.
[5] Georgiades P, Pudney P D, Rogers S, et al.Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins[J]. Plos One, 2014, 9(8): 1-11.
[6] Minaiyan M, Ghannadi A, Mahzouni P, et al.Comparative study of berberis vulgaris fruit extract and berberine chloride effects on acetic acid-induced colitis in rats[J]. Iranian Journal of Pharmaceutical Research Ijpr, 2011, 10(1): 97-104.
[7] Masako Nakanishi, Antoine Menoret, Takuji Tanaka, et al.Selective PGE2 suppression colon carcinogenesis and modifies local mucosal immunity[J]. Cancer Prevention Research, 2011, 4(8): 1198-1208.
[8] 胡敏鹂, 华宏军, 杨小云, 等. IBS-D患者直肠乙状结肠交界黏膜MC活化及类胰蛋白酶的变化及作用研究[J]. 中国现代医生, 2015, 53(24): 1-4.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References