The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

LI Shigang; ZHENG Qianqian; HE Jiangang; XIAO Changyi; LIU Wei; WANG Hui; LIU Jincheng

doi:10.13305/j.cnki.jts.2016.03.003

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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (3) : 245-249. DOI: 10.13305/j.cnki.jts.2016.03.003

The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

LI Shigang^1,2, ZHENG Qianqian², HE Jiangang¹, XIAO Changyi^1,2, LIU Wei^1,2, WANG Hui^1,3, LIU Jincheng¹

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Abstract

The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels.

Key words

colon tissue / Hubei Qingzhuan tea / IBS-D / inflammatory cytokines / visceral sensitivity

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LI Shigang, ZHENG Qianqian, HE Jiangang, XIAO Changyi, LIU Wei, WANG Hui, LIU Jincheng. The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model[J]. Journal of Tea Science. 2016, 36(3): 245-249 https://doi.org/10.13305/j.cnki.jts.2016.03.003

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