普洱茶水提物与硝苯地平联用降压效果研究

doi:10.13305/j.cnki.jts.2015.02.009

茶叶科学 ›› 2015, Vol. 35 ›› Issue (2): 165-170.doi: 10.13305/j.cnki.jts.2015.02.009

普洱茶水提物与硝苯地平联用降压效果研究

李彦川, 李欣欣, 周王谊, 李长文, 马晓慧^*

天士力研究院,天津 300410

收稿日期:2014-07-11 修回日期:2015-01-07 出版日期:2015-04-15 发布日期:2019-08-23
通讯作者: *maxiaohui@tasly.com
作者简介:李彦川,男,助理研究员,主要从事心血管药理学研究。

Research on Combined Anti-hypertensive Effect of Pu'er Tea Extract and Nifedipine

LI Yanchuan, LI Xinxin, ZHOU Wangyi, LI Changwen, MA Xiaohui^*

Tasly Institute, Tianjin 300410, China

Received:2014-07-11 Revised:2015-01-07 Online:2015-04-15 Published:2019-08-23

摘要/Abstract

摘要： 观察普洱茶水提物对硝苯地平降压效果的影响。采用雄性SHR大鼠50只,按照平均尾动脉压随机分为模型组（M组）、硝苯地平3.1βmg·kg^-1组（1/2临床剂量）(N.L组)、硝苯地平6.2βmg·kg^-1组（临床剂量）（N.H组）、硝苯地平3.1βmg·kg^-1+普洱茶水提物0.5βg·kg^-1组（N.L+D.L组）、硝苯地平3.1βmg/kg+普洱茶水提物1.0βg·kg^-1组（N.L+D.H组）,每组10只,另设10只动物作为正常对照组（C组）。分组次日灌胃给予相应药物,每天2次,上午给予硝苯地平,下午给予普洱茶水提物,灌胃间隔3~4βh,每周对各组动物血压进行检测,持续4周。结果表明,大鼠给药4周后,硝苯地平6.2βmg·kg^-1组大鼠尾动脉平均血压为(139±6)βmmHg（1βmmHg=0.133βkPa）,与M组的(157±13)βmmHg比较显著降低（P<0.05）;N.L+D.H组大鼠尾动脉平均血压为(136±11)βmmHg,与M组的(157±13)βmmHg比较显著降低（P<0.05）,与硝苯地平6.2βmg·kg^-1组的（139±6）βmmHg相比,降压效果相当（P>0.05）。研究表明,普洱茶水提物配合硝苯地平使用,可增强硝苯地平对SHR大鼠的降压功效,其降压效果与临床剂量硝苯地平单独使用相当,且对心脏具有一定程度的保护作用。

关键词: 普洱茶水提物, 硝苯地平, 自发性高血压大鼠

Abstract: To explore combined anti-hypertensive effect of Pu'er tea extract and Nifedipine in SHR, 50 SHR rats were randomly divided into different model groups, N.L group, N.H group, N.L+D.L group and N.L+D.H group, 10 rats for each group. Wistar rats were selected as control group. Pu'er tea extract and Nifedipine were administered to SHR for 4 weeks. The blood pressure was measured once per week. Results showed that mean blood pressure was significantly reduced in spontaneous hypertension rats after treatment with 6.2βmg·kg^-1 nifedipine, compared with model controls (P<0.05). The 3.1βmg·kg^-1 nifedipine also has a tendency to decrease blood pressure. Combined antihypertensive effect of Pu'er tea extract and nifedipine was enhanced compared with nifedipine alone. The nifedipine showed anti-hypertensive effect on spontaneous hypertension rats in a dose-dependent manner. Pu'er tea extract can enhance the antihypertensive effect of nifedipine, and showed a certain degree of protective on heart.

Key words: Pu'er tea extract, nifedipine, spontaneous hypertension rats

中图分类号:

TS272.5⁺4

李彦川, 李欣欣, 周王谊, 李长文, 马晓慧. 普洱茶水提物与硝苯地平联用降压效果研究[J]. 茶叶科学, 2015, 35(2): 165-170. doi: 10.13305/j.cnki.jts.2015.02.009.

LI Yanchuan, LI Xinxin, ZHOU Wangyi, LI Changwen, MA Xiaohui. Research on Combined Anti-hypertensive Effect of Pu'er Tea Extract and Nifedipine[J]. Journal of Tea Science, 2015, 35(2): 165-170. doi: 10.13305/j.cnki.jts.2015.02.009.

普洱茶水提物与硝苯地平联用降压效果研究

Research on Combined Anti-hypertensive Effect of Pu'er Tea Extract and Nifedipine

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