取健康家兔10只,随机分为2组,单剂量静注和灌服脂质体儿茶素（Catechin Liposome）25mg/kg。用高效液相色谱法测定血浆中儿茶素原药质量浓度。房室模型分析表明：健康家兔静注儿茶素脂质体的药时数据符合无吸收二室开放模型,主要药物动力学参数为：t_1/2α0.18±0.01βh,t_1/2β1.52±0.08βh,V_d4.48±0.24L,Cl_B2.05±0.07L/h,AUC29.20±1.00βmg/（L.h）,K₁₀1.64±0.19h^–1,K₂₁1.08±0.06h^–1,K₁₂1.61±0.19h^–1。健康家兔灌服脂质体儿茶素的药时数据符合一级吸收一室开放模型,主要药物动力学参数为：t_1/2k_a 0.27±0.03βh,t_1/2k_e 1.72±0.04βh,t_max0.87±0.05βh,C_max6.53±0.62βmg/L,AUC 25.90±1.34βmg/（L.h）,F 88.60±5.73%。脂质体儿茶素在健康家兔体内的药动学特征是：吸收迅速,达峰时间较短,消除慢,半衰期延长,表现分布容积大,口服生物利用度高。结果表明：儿茶素经脂质体包封后,药物动力学及组织分布均发生了明显改变。

Pharmacokinetics and bioavailability of Catechin Liposome were studied in 10 healthy rabbits following single intravenous (25mg/kg) and oral administration (25mg/kg)of the drug. Plasma concentrations of. Catechin Liposome were determined by high-performance liquid chromatography. The concentration-time data were fitted to a two-compartment model following a single intravenous injection in rabbits. The main pharmacokinetic parameters were as follows: distribution half-life (t_1/2α) (0.18±0.01)h,elimination half-life (t_1/2β) (1.52±0.08)h,apparent distribution volume (Vd) (4.48±0.24)L total body clearance (Cl_B) (2.05±0.07)L/h,the area under curve (AUC) (29.20±1.00)mg/(L.h). The drug concentration-time data also were fitted to a one-compartment open model with first order absorption after a single oral administration Catechin Liposome. The pharmacokinetic parameters were as follows: t_1/2k_α (0.27±0.03)h, t_1/2k_e(1.72±0.04)h, t_max (0.87±0.05) h, C_max 6.53±0.62βmg/L, AUC 25.90±1.34βmg/(L.h), bioavailability F 88.60±5.73%. Pharmacokinetic characteristics of Catechin Liposome in healthy rabbits showed a rapid absorption, the time to reach Cmax is short, slow elimination, long half-life, large apparent distribution volume, and high bioavailability of oral administration. The results showed：after Catechin was prepared in liposome form, the tissue distribution and pharmacokinetics were changed significantly.