选取链脲佐菌素（Streptozotocin,STZ）致糖尿病大鼠模型,研究普洱茶水提物与吡格列酮联合应用对糖尿病大鼠的降糖作用,以明确普洱茶水提物是否对降糖药物具有协同作用,在控制血糖前提下能否减少降糖药用量。根据血糖水平按照普洱茶水提物与吡格列酮联合用药和单独用药的方式将动物分成不同的组别,包括对照、模型、吡高、吡低、吡高+PTE低、吡高+PTE高、吡低+PTE低、吡低+PTE高各实验组,每天灌胃给药2次,连续给药4周。在试验期间观察动物状态,每周大鼠尾部静脉针刺取血,测定动物的空腹血糖值;于给药第4周测定大鼠葡萄糖耐量并检测血清中糖化血清蛋白（Glucosylated serum proteins,GSP）和胰岛素（Insulin,INS）含量并计算胰岛素敏感指数。结果发现普洱茶水提物与吡格列酮混合用药能显著抑制空腹血糖的升高,下调灌胃葡萄糖后30、60、120βmin血糖的升高,显著抑制葡萄糖负荷血糖曲线下面积（Area under concentration-time curve,AUC）;给药各组能显著降低大鼠血清GSP含量。在服用吡格列酮的同时辅助饮用普洱茶水提物,可以减少服用吡格列酮的用药量而不减弱吡格列酮的降糖效果。

The aim of this study was to investigate the hypoglycemic effect of Pu′er tea extract combined with pioglitazone on diabetic model rat induced by STZ and clarify the synergistic effect of Pu′er tea extract with hypoglycemic drugs and the amount of hypoglycemic drugs could be reduced under the premise to control blood glucose. According to the blood glucose levels and the different ways of Pu′er tea extract combined with pioglitazone, all animals were divided into different groups including control, model, high P, low P, HP+LPTE, HP+HPTE, LP+LPTE, LP+HPTE, orally administered twice a day for consecutive 4 weeks. Animals’ status was observed during the test, and rat tail veins were weekly acupunctured to measure fasting blood glucose. The glucose tolerance, GSP and insulin levels in serum were determined in fourth week and insulin sensitivity index was calculated. The results showed that Pu′er tea extract combined with mixed medication pioglitazone could significantly suppress fasting blood glucose, lower blood glucose at 30βmin, 60βmin, 120βmin after administration of glucose, and reduce the AUC as compared with other groups. Additionally, serum GSP levels were also reduced after treatment with Pu′er tea extract combined with pioglitazone. These results suggest that pioglitazone combined with pu′er tea extract could reduce the amount of pioglitazone without reducing pioglitazone’s hypoglycemic effect.