血小板活化是许多心血管疾病的发病基础,抗血小板药物能够在不同水平阻断血小板聚集作用的级联反应。临床医学和动物实验证实,茶叶及有效成分对血小板活化具有抑制作用,在抗血栓活性上表现出一定的构效关系。本文从饮茶及茶叶成分对血小板聚集、血栓、凝血系统等方面的体内外研究进展进行综述,探讨茶叶抑制血小板活化的不同作用机理,有助于系统阐明茶叶抗血栓、预防心血管疾病功能。
Platelet activation is the basis of the incidence of many cardiovascular disease, antiplatelet drugs could block the cascade of platelet aggregation in different levels. As confirmed by clinical research and animal experiments, tea and tea ingredients can inhibit platelet aggregation. Catechins exhibit a structure-activity relationship in antiplatelet effect. This review summarized recent progress in the effect of tea and tea ingredients on platelet activity or platelet aggregation in vitro, in vivo and ex vivo, and also the effect on thrombus and coagulation system. The mechanism of anti-aggregatory effect of tea is explored, which provide further confirmation for its antithrombotic function and the preventive effect for cardiovascular disease.
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