采用丙酮、水、氯仿、乙酸乙酯和正丁醇连续萃取普洱茶,旋转蒸发后冷冻干燥得到氯仿层、乙酸乙酯层、正丁醇层以及剩余水层4个主要分离组分,利用不同的组分灌胃经过肥胖造模处理的ICR小鼠,与普洱茶总水提取物和减肥药左旋肉碱进行比较,研究普洱茶不同组分对ICR肥胖小鼠的降脂减肥作用。实验结果表明,普洱茶总水提取物、乙酸乙酯萃取组分、剩余水层组分均对肥胖ICR小鼠具有很好的降脂减肥作用。其中乙酸乙酯层和剩余水层抑制脂肪累积（抑制率分别是24.7%和22.5%）的效果略差于减肥药物左旋肉碱（抑制率38.8%）,但在改善血清指标尤其是提高HDL-C水平方面（提高率为61.7%和73.4%）显著优于左旋肉碱（9.4%）,肝脏指标检测也得到了类似的结论,揭示普洱茶降脂减肥作用的主要成分可能存在于乙酸乙酯层和（或）剩余水层中。

In this study, Pu-erh tea was extracted with acetone, water, chloroform, ethyl acetate, and n-butanol. then, the extraction was concentrated with rotary evaporation and dried with lyophilizer into chloroform layer, ethyl acetate layer, n-butanol layer and surplus water layer extracts, which were used to administer ICR obese mouse for analyzing the lipid-lowering and anti-obesity effects. The experimental results demonstrated that the pu-erh tea total extract, ethyl acetate extract and surplus water extract are all effective on lipid-lowering and anti-obesity of ICR obese mouse, and the effects of ethyl acetate extract and surplus water extract on inhibiting fat accumulation（inhibition ratio was 24.7% and 22.5%）was slightly less than those in the L-carnitine （38.8%）, but the effect on improving HDL-C level(61.7% and 73.4%) significantly superior to that in the L-carnitine (9.4%), the similar results were obtained in the mice liver, which suggest that the key lipid-lowering and anti-obesity function components were existed in the ethyl acetate layer and (or) surplus water layer extracts of pu-erh tea.