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云南不同地区晒青茶茶汤对PTPs靶标的抑制效果

  • 王立波 ,
  • 梁名志 ,
  • 付学奇 ,
  • 李友勇 ,
  • 王平盛 ,
  • 马伟 ,
  • 蔡丽 ,
  • 季鹏章
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  • 1. 云南省农业科学院茶叶研究所,云南 勐海 666201;
    2. 吉林大学生命科学学院,吉林 长春 130023
王立波(1982— ),山东东营人,硕士,主要从事名特优茶研发及茶叶生化研究。

收稿日期: 2009-07-15

  修回日期: 2010-05-26

  网络出版日期: 2019-09-11

基金资助

云南省自然科学重点基金(2006C0012Z)

Inhibitory Effects of Sun-dried Green Tea Soup from Different Areas of Yunnan on PTPs Targets

  • WANG Li-bo ,
  • LIANG Ming-zhi ,
  • FU Xue-qi ,
  • LI You-yong ,
  • WANG Ping-sheng ,
  • MA Wei ,
  • CAI Li ,
  • JI Peng-zhang
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  • 1. Tea Research Instutite, Yunnan Academy of Agricultural Sciences, Menghai 666201, China;
    2. College of Life Science, Jilin University, Changchun 130023, China

Received date: 2009-07-15

  Revised date: 2010-05-26

  Online published: 2019-09-11

摘要

以抑制率和IC50为指标,分析测定了云南省不同地区晒青茶茶汤对PTP1B、SHP-1、SHP-2、HePTP 4个PTPs靶标的抑制效果,以此来比较探讨普洱茶原料的保健功能性差异。结果表明,不同的晒青茶茶汤对PTPs靶标的抑制效果差异较大;73-11晒青茶茶汤对PTP1B、SHP-1、SHP-2、HePTP 4个靶标均有很好的抑制效果,其抑制率均>92.0%,IC50均<5.5 mg/mL。由此得出,不同普洱茶原料晒青茶茶汤的保健功效有所差异。

关键词: ; PTPs; 靶标; 抑制效果

本文引用格式

王立波 , 梁名志 , 付学奇 , 李友勇 , 王平盛 , 马伟 , 蔡丽 , 季鹏章 . 云南不同地区晒青茶茶汤对PTPs靶标的抑制效果[J]. 茶叶科学, 2010 , 30(4) : 309 -312 . DOI: 10.13305/j.cnki.jts.2010.04.012

Abstract

Using inhibitory rate and IC50 as indexes, the inhibitory effects of sun-dried green tea soup from different areas of Yunnan on 4 targets of PTP1B, SHP-1, SHP-2, HePTP were investigated to compare the functional differences of Pu’erh tea raw materals. Results indicated that the inhibitory effects of different sun-dried green tea were different significantly. Besides, tea cultivar 73-11 sample showed very good inhibitory effect on these four targets, its inhibitory rate and IC50 is >92.0% and <5.5 mg/mL respectively. Based on these conclusions, tea soup of Pu-erh tea’s raw material sun-dried tea possessed different functional effects.

Key words: tea; PTPs; targets; inhibitory effect

参考文献

[1] Ostman A, Hellberg C, Bǒhmer F D.Protein-tyrosine Phosphatases and Cancer[J]. Nat Rev Cancer, 2006, 6(4): 307-320.
[2] Tonks N K.Protein Tyrosine Phosphatases: from Genes, to Function, to Disease[J]. Nature Rev Mol Cell Biol, 2006, 7(11): 833-846.
[3] Andersen J N, Jansen P G, Echwald S M, et a1. A Genomic Perspective on Protein Tyrosine Phosphatases: Gene Structure, Pseudo genes, and Genetic Disease Linkage[J]. FASEB J, 2004, 18(1): 8-30.
[4] LI Wa n-nan, ZHUANG Yan, LI He, et a1. Purification and Characterization of the Catalytic Domain of Protein Tyrosine Phosphatase SHP-1 and Preparation of Anti-ΔSHP-1 Antibodies[J]. Chemical Research of Chinese Universities, 2008, 24(5): 592-596.
[5] 刘巍, 徐为人. SHP-2蛋白质酪氨酸磷酸酶的研究进展[J]. 国际检验医学杂志, 2006, 27(9): 814-816.
[6] Qu CK.The SHP-2 tyrosine phosphatase:signaling mechanisms and biological functions[J]. Cel1 Res, 2000, 10(4): 279-288.
[7] 俞冬熠, 张全启, 齐洁, 等. HePTP抑制BCR诱导的未成熟B淋巴细胞的凋亡[J]. 同济大学学报: 医学版, 2006, 27(4): 27-31.
[8] 梁名志. 普洱茶科技探究[M]. 昆明: 云南科技出版社, 2009: 170.
[9] 张顺高. 普洱茶保健功效揭秘[M]. 昆明: 云南科技出版社, 2008: 27, 34-36.
[10] 李婉南, 李莹, 庄妍, 等. 蛋白质酪氨酸磷酸酶SHP-1的中药抑制剂筛选[J]. 吉林大学学报: 理学版, 2008, 46(6): 1211-1216.
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