湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响

李世刚; 郑倩倩; 何建刚; 肖长义; 柳蔚; 王慧; 刘锦程

doi:10.13305/j.cnki.jts.2016.03.003

茶叶科学 >

2016 , Vol. 36 >Issue 3: 245 - 249

DOI: https://doi.org/10.13305/j.cnki.jts.2016.03.003

湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响

李世刚 ,
郑倩倩 ,
何建刚 ,
肖长义 ,
柳蔚 ,
王慧 ,
刘锦程

展开

1. 湖北长盛川青砖茶研究所, 湖北宜昌 443002;
2. 三峡大学医学院,湖北宜昌 443002;
3. 三峡大学生物工程与制药工程学院,湖北宜昌 443002

李世刚,男,博士,副教授,主要从事中药药效与新药研究。E-mail: fox201@163.com

收稿日期: 2015-12-21

网络出版日期: 2019-08-23

收起

The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

LI Shigang ,
ZHENG Qianqian ,
HE Jiangang ,
XIAO Changyi ,
LIU Wei ,
WANG Hui ,
LIU Jincheng

Expand

1. Long Cheng Chuan Qingzhuan Tea Research Institute of Hubei Province, Yichang 443002, China;
2. Medical College of China Three Gorges University, Yichang 443002, China;
3. Biotechnology and Pharmaceutical Engineering College of China Three Gorges University, Yichang 443002, China

Received date: 2015-12-21

Online published: 2019-08-23

Fold

摘要

研究了湖北青砖茶对腹泻型肠易激综合征（IBS-D）模型大鼠肠道的影响。结果表明,与正常组相比,模型组的痛阈值明显降低,血清中炎症因子前列腺素2（PGE2）、肿瘤坏死因子（TNF-α）、类胰蛋白酶的含量明显增加;与模型组比较,湖北青砖茶低剂量组、高剂量组能够显著升高痛阈值,而血清中炎症因子PGE2、TNF-α、类胰蛋白酶的含量显著降低,且具有剂量依赖性。由此表明湖北青砖茶可降低IBS-D模型大鼠的肠道敏感性,其作用机制可能与血清中PGE2、TNF-α和类胰蛋白酶含量的降低有关。

关键词： 湖北青砖茶; IBS-D; 肠道敏感性; 结肠组织; 炎症因子

本文引用格式

李世刚 , 郑倩倩 , 何建刚 , 肖长义 , 柳蔚 , 王慧 , 刘锦程 . 湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响[J]. 茶叶科学, 2016 , 36(3) : 245 -249 . DOI: 10.13305/j.cnki.jts.2016.03.003

Abstract

The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels.

Key words： Hubei Qingzhuan tea; IBS-D; visceral sensitivity; colon tissue; inflammatory cytokines

参考文献

[1] Thompson W, Longstreth G, Drossman D, et al. Functional bowel disorders and functional abdominal pain [J]. Gut, 1999, 45(3): II43-II47.
[2] Nakanishi M, Menoret A, Tanaka T, et al.Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity[J]. Cancer Prevention Research, 2011, 4(8): 1198-1208.
[3] Veek P P J V D, Marlies V D B, Kroon Y E D, et al. Role of tumor necrosis factor-α and interleukin-10 gene polymorphisms in irritable bowel syndrome[J]. American Journal of Gastroenterology, 2005, 100(11): 2510-2516.
[4] 郭朝书, 王承党. 肥大细胞及类胰蛋白酶在肠易激综合征内脏敏感性中的作用[J]. 国际消化病杂志, 2010, 30(1): 4-5.
[5] Georgiades P, Pudney P D, Rogers S, et al.Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins[J]. Plos One, 2014, 9(8): 1-11.
[6] Minaiyan M, Ghannadi A, Mahzouni P, et al.Comparative study of berberis vulgaris fruit extract and berberine chloride effects on acetic acid-induced colitis in rats[J]. Iranian Journal of Pharmaceutical Research Ijpr, 2011, 10(1): 97-104.
[7] Masako Nakanishi, Antoine Menoret, Takuji Tanaka, et al.Selective PGE2 suppression colon carcinogenesis and modifies local mucosal immunity[J]. Cancer Prevention Research, 2011, 4(8): 1198-1208.
[8] 胡敏鹂, 华宏军, 杨小云, 等. IBS-D患者直肠乙状结肠交界黏膜MC活化及类胰蛋白酶的变化及作用研究[J]. 中国现代医生, 2015, 53(24): 1-4.

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract

参考文献