Welcome to Journal of Tea Science,Today is

Research on the Anti-diabetes and Anti-hyperlipidenmia Function of Monomers in Pu-erh Tea

  • ZHANG Dong-ying ,
  • SHAO Wan-fang ,
  • LIU Zhong-hua ,
  • LIU Ya-lin ,
  • HUANG Ye-wei
Expand
  • 1. College of Long Run Pu-erh Tea, Y N A U, Kunming 650201, China;
    2. Tea Key Lab of the Ministry of National Teaching, HNAU, Changsha 410128, China;
    3.Yunnan Agriculture Department, Kunming 650201, China

Received date: 2008-07-18

  Revised date: 2008-11-17

  Online published: 2019-09-06

Abstract

The anti-diabetes and anti-hyperlipidenmia function of Uracil and Gallic acid from Pu-erh Tea was studied by the PPARδ, PPARα, PPARγ, FXR, LXR, 3T3-L1 and α-amylase models which are related to glucose and lipid metabolism. Result showed that: Uracil and gallic acid were active to the models of PPARγ, FXR, LXR, especially, Gallic acid showed distinct active effect on PPARγ, the value was as high as 2.438 which showed the same effect as positive drug, and weak activity on PPARδ, PPARα, 3T3-L1 models. Gallic acid showed better activity than Uracil in the PPARγ model and Uracil showed better activity than gallic acid in the FXR and LXR models. Furthermore, Gallic acid showed strongth inhibition on the activity of α-amylase. It can provide some theoretical basis on the mechanism of Pu-erh tea on the anti-diabetes and anti-hyperlipidenmia activity.

Cite this article

ZHANG Dong-ying , SHAO Wan-fang , LIU Zhong-hua , LIU Ya-lin , HUANG Ye-wei . Research on the Anti-diabetes and Anti-hyperlipidenmia Function of Monomers in Pu-erh Tea[J]. Journal of Tea Science, 2009 , 29(1) : 41 -46 . DOI: 10.13305/j.cnki.jts.2009.1.007

References

[1] 周志宏, 杨崇仁. 云南普洱茶原料晒青毛茶的化学成分[J]. 云南植物研究, 2000, 22(3): 343~350.
[2] 吕海鹏. 普洱茶化学成分与抗氧化活性研究[M]. 杭州: 中国农业科学院硕士研究生论文, 2005.
[3] 张冬英, 刘仲华, 刘亚林, 等. 高通量筛选法对普洱茶降血糖降血脂作用研究[J]. 茶叶科学, 2006, 26(1): 49~53.
[4] 傅冬和, 刘仲华, 黄建安, 等. 高通量筛选研究茯砖茶对FXR模型的作用[J]. 食品科学, 2007, 28(5): 331~334.
[5] 傅冬和, 刘仲华, 黄建安, 等. 茯砖茶不同萃取物对消化酶活性的影响[J]. 茶叶科学, 2008, 28(1): 62~66.
[6] 张冬英. 普洱茶降糖降脂活性成分研究[M]. 长沙: 湖南农业大学博士研究生论文, 2006.
[7] Zhang Y, Repa JJ, Gauthier K, et al. Regulation of lipoprotein lipase by the oxysterol reseptors, LXRalpha and LXRbeta[J]. J Biol Chem, 2001, 276(46): 43018~43024.
[8] Urizar NL, Dowhan DH, Moore DD.The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression[J]. J Biol Chem, 2000, 275(50): 39313~39317.
[9] Lee C H, Chawla A, Urbiztondo N, et a1.Transcriptional repression of atherogenic inflammation: modulation by PPAR-delta[J]. Science, 2003, 302: 455~457.
[10] Frohnet B I, Hui T Y, Bernlohr DA.Identification Of functional peroxisome proliferators-responsive element in murine fatty acid transport protein gene[J]. J Biol Chem, 1999, 274: 3970~3977.
[11] Schultz JR, Tu H, Luk A, et a1. Role of LXRs in control of lipogenesis[J]. Genes Dev, 2000, 14: 2831-2838.
[12] Urizar N L, Liveryman A B, Dodd’s DT, et a1. A natural product that lowers cholesterol as antagonist ligand for FXR[J]. Science, 2002, 296: 1703~1706.
[13] 李肖玲, 崔岚, 祝德秋. 没食子酸生物学作用的研究进展[J]. 中国药师, 2004, 7(10): 767~769.
Outlines

/