To explore combined anti-hypertensive effect of Pu'er tea extract and Nifedipine in SHR, 50 SHR rats were randomly divided into different model groups, N.L group, N.H group, N.L+D.L group and N.L+D.H group, 10 rats for each group. Wistar rats were selected as control group. Pu'er tea extract and Nifedipine were administered to SHR for 4 weeks. The blood pressure was measured once per week. Results showed that mean blood pressure was significantly reduced in spontaneous hypertension rats after treatment with 6.2βmg·kg-1 nifedipine, compared with model controls (P<0.05). The 3.1βmg·kg-1 nifedipine also has a tendency to decrease blood pressure. Combined antihypertensive effect of Pu'er tea extract and nifedipine was enhanced compared with nifedipine alone. The nifedipine showed anti-hypertensive effect on spontaneous hypertension rats in a dose-dependent manner. Pu'er tea extract can enhance the antihypertensive effect of nifedipine, and showed a certain degree of protective on heart.
LI Yanchuan
,
LI Xinxin
,
ZHOU Wangyi
,
LI Changwen
,
MA Xiaohui
. Research on Combined Anti-hypertensive Effect of Pu'er Tea Extract and Nifedipine[J]. Journal of Tea Science, 2015
, 35(2)
: 165
-170
.
DOI: 10.13305/j.cnki.jts.2015.02.009
[1] World health organization. 2012 WORLD HEALTH STATISTICS[J]. 中国全科医学, 2012, 15(8c): 2844.
[2] Redwood H.Hypertension, society, and public policy[J]. Eur Heart J, 2007, 9(suppl B): B13.
[3] 李欣欣, 莫红梅, 马晓慧, 等. 普洱茶水提物对自发性高血压大鼠降压研究[J]. 茶叶科学, 2012, 32(5): 457-460.
[4] Lin PP, Hsieh YM, Kuo WW.Suppression of TLR-4-related inflammatory pathway and anti-fibrosis effects of probiotic-fermented purple sweet potato yogurt in hearts of spontaneously hypertensive rats[J]. Chin J Physiol, 2013; 56(3): 174-183.
[5] 杨芮, 刘凯, 陈晓平. 圣地红景天对自发性高血压大鼠左室重构的影响及其机制探讨[J].四川大学学报: 医学版, 2013(2): 201-204.
[6] 王静, 杜乃立, 赵卓, 等. 自发性高血压大鼠心肌声学密度与心肌纤维化的关系及药物干预研究[J]. 山东大学学报: 医学版, 2009(1): 50-55.
[7] Anversea P, Hagopian M, Alder V.Quantitative radio autographic localization of protein synthesis in experimental cardiac hypertrophy[J]. Lab Invest, 1973, 29(3): 282.
[8] Lopez Salazar B, Ravassa Albeniz S, Arias Guedon T.Altered fibrillar collagen metabolism in hypertensive heart failure. Current understanding and future Prospects[J]. Rev Esp Cardiol, 2006, 59(10): 1047-1057.
[9] 江新凤, 邵宛芳, 侯艳. 普洱茶预防高血脂症及抗氧化作用的研究[J]. 云南农业大学学报, 2009(5): 705-711.
[10] 王岳飞, 徐平, 李磊, 等. 茶多酚与几种天然抗氧化物质的协同作用研究[J]. 茶叶科学, 2010, 30(2): 109-114.
[11] 吕海鹏, 谷记平, 林智, 等. 普洱茶的化学成分及生物活性研究进展[J]. 茶叶科学, 2007, 27(1): 8-18.
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