信阳毛尖茶水提物缓解PM2.5致大鼠肺损伤的研究

刘建军; 李美凤; 张静; 田丽丽; 邓燕莉; 林海燕; 黄建安; 刘仲华

doi:10.13305/j.cnki.jts.2021.04.006

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茶叶科学 ›› 2021, Vol. 41 ›› Issue (4) : 525-534. DOI: 10.13305/j.cnki.jts.2021.04.006

研究报告

信阳毛尖茶水提物缓解PM_2.5致大鼠肺损伤的研究

刘建军^1,2,3, 李美凤³, 张静^1,2,3, 田丽丽^1,2,4, 邓燕莉^1,2,3, 林海燕^1,2, 黄建安^1,2,*, 刘仲华^1,2,*

作者信息 +

A Study of Xinyang Maojian Tea Water Extracts on Relieving Lung Injury Caused by PM_2.5

LIU Jianjun^1,2,3, LI Meifeng³, ZHANG Jing^1,2,3, TIAN Lili^1,2,4, DENG Yanli^1,2,3, LIN Haiyan^1,2, HUANG Jian′an^1,2,*, LIU Zhonghua^1,2,*

Author information +

文章历史 +

摘要

以健康雄性SD大鼠为试验对象,信阳毛尖茶水提物为受试物,气管滴注PM_2.5（Fine particulate matter）悬浮液建立慢性肺损伤模型,研究信阳毛尖茶水提物对滴注PM_2.5大鼠体重增长率、肺组织形态学、肺组织病理学的影响,并对大鼠血清和支气管肺泡灌洗液（BALF）的生化指标进行测定。结果表明,信阳毛尖茶水提物一定程度上具有拮抗PM_2.5导致的大鼠体重增长率降低以及肺部损伤等作用;此外,信阳毛尖茶水提物可有效阻止大鼠血清和BALF中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、免疫球蛋白G（IgG）含量和乳酸脱氢酶（LDH）活性上升,以及超氧化物歧化酶（SOD）活性的下降,其效果与浓度呈良好的剂量关系。

Abstract

In this study, the healthy male sprague-dawley (SD) rats were taken as experimental subjects, and the water extracts of Xinyang Maojian tea were used as test substances, while intratracheal instillation of PM_2.5 suspension was established as chronic pulmonary injury model. Rats serum and biochemical indexes of bronchoalveolar lavage fluid (BALF) were tested. The results show that the tea extracts had antagonism effects on the reduce of rats growth rate and the lung injury caused by PM_2.5. Furthermore, the tea water extracts could effectively lower the increase of IL-1β, IL-6, TNF-α, IgG and the activity of LDH, and keep the activity of SOD in rats serum and BALF, showing a dose-dependent effects.

导出引用

刘建军, 李美凤, 张静, 田丽丽, 邓燕莉, 林海燕, 黄建安, 刘仲华. 信阳毛尖茶水提物缓解PM_2.5致大鼠肺损伤的研究[J]. 茶叶科学. 2021, 41(4): 525-534 https://doi.org/10.13305/j.cnki.jts.2021.04.006

LIU Jianjun, LI Meifeng, ZHANG Jing, TIAN Lili, DENG Yanli, LIN Haiyan, HUANG Jian′an, LIU Zhonghua. A Study of Xinyang Maojian Tea Water Extracts on Relieving Lung Injury Caused by PM_2.5[J]. Journal of Tea Science. 2021, 41(4): 525-534 https://doi.org/10.13305/j.cnki.jts.2021.04.006

中图分类号： S571 R563

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