Abstract: The edible safety of the compound of Tea-polyphenols and American ginseng was investigated according to “the Standard of Health Food Test and Assesment”. Acute toxicity test in mice showed that LD₅₀ was higher than 10.0 g/kg.Bw, all three genetic tests showed negative results, 30 days feeding test showed that the physical appearance, behaviors, weights, organ coefficients, the indexes of hematology and biochemistry in rats have no significant difference comparing with the control group, also, no significant external appearance and pathological changes of various organs including liver, heart, spleen, kidney, stomach, intestines, testicle, and ovary were discovered. All results suggested that the compound has no acute toxicity, no genotoxicity, and high in edible safety.

Key words: tea-polyphenols, american ginseng, acute toxicity, genotoxicity, edible safety