Welcome to Journal of Tea Science,Today is

Journal of Tea Science ›› 2019, Vol. 39 ›› Issue (6): 631-640.doi: 10.13305/j.cnki.jts.2019.06.002

Previous Articles     Next Articles

Protective Effect of Fu Brick Tea on Intestinal Mucosal Barrier and Liver Injury in NAFLD Rats

ZUO Gaolong1,2, CHEN Meiyan1,2, LIN Yong1,2,3,*, LIN Haiyan1,2,3, LIU Zhonghua1,2,3, WU Wenliang1,4   

  1. 1. Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China;
    2. National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China;
    3. Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China;
    4. Tea Research Institute, Hunan Academy of Agricultural Sciences, Changsha 410125, China
  • Received:2019-04-08 Revised:2019-07-08 Online:2019-12-15 Published:2019-12-24

Abstract: To explore the protective effect of Fu brick tea on intestinal mucosal barrier and liver injury in rats with high-fat induced non-alcoholic fatty liver disease (NAFLD). SD male rats were randomly divided into normal, NAFLD, low-dose and high-dose Fu brick tea groups, 8 rats each group. The establishment of NAFLD rat model and the intervention effect of Fu brick tea were evaluated by analyzing the feed intake, weight change, blood lipid index, liver index and pathological section of rats. Intestinal integrity and intestinal permeability was assessed by pathological and PAS staining sections of jejunum and colon, villus height/crypt depth (V/C value) serum diamine oxidase (DAO) activity and lipopolysaccharide (LPS) activity. Intestinal-related inflammation was assessed by the number of jejunum intraepithelial lymphocytes (JIL) and the activity of serum tumor necrosis factor-alpha (TNF-α). The results show that Fu brick tea could reduce the feed intake andbody weight of NAFLD rats, decrease blood lipid levels, reduce the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, and inhibit lipid accumulation and inflammation in the liver. Fu brick tea also reduced the levels of serum inflammatory factors TNF-α and serum LPS and increased the activity of serum DAO. Moreover, Fu brick tea inhibited inflammatory cell infiltration in jejunum and colon villi of NAFLD rats, reduced the jejunum villus shedding, fracture, sparse and disorder, increased the jejunum villus V/C value, and decreased the number of jejunum intraepithelial lymphocytes, and increased the number of goblet cells in the jejunum and colon. These data indicate that Fu brick tea could effectively improve the intestinal mucosal barrier and liver injury induced by high-fat diet, which could be used to prevent and treat NAFLD.

Key words: Fu brick tea, non-alcoholic fatty liver disease (NAFLD), intestinal barrier

CLC Number: