In the present study, the locomotor activities and disappearance of righting reflex on ICR mice were employed to evaluate effects of theanine on the sedative and hypnosis induced by pentobarbital sodium. Results showed that theanine alone decreased locomotor activity in dose-dependent manner and had no stimulant effect, 50% inhibition dose of locomotor activity was 0.8518 g/kg, low doses of theanine(≤1.0 g/kg) enhanced inhibition effect of locomotor activity induced by pentobarbital sodium(5 mg/kg), however, high dose (2.0 g/kg) of theanine reversed the inhibition, meanwhile, theanine enhanced hypnosis induced by pentobarbital sodium(25 mg/kg) in dose-dependent manner. It is concluded that theanine changed locomotor activity of mice induced by low dose of pentobarbital sodium(5 mg/kg) in dimensional change (“U” shape style), but not higher dose of pentobarbital sodium(25 mg/kg).
YU Xi-chong
,
WU Bo-la
,
ZHU Tong-jun
,
YANG Wei
. Theanine Effects on Sedative and Hypnosis Induced by Pentobarbital Sodium In ICR Mice[J]. Journal of Tea Science, 2009
, 29(4)
: 257
-262
.
DOI: 10.13305/j.cnki.jts.2009.4.002
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