Protective Effects of Fu Brick Tea Extracts on Inflammatory Bowel Disease Induced by Dextran Sulfate Sodium in Mice

HU Ankai; YAO Liyun; ZHAO Yueling; LIU Chang; WANG Yuefei; XU Ping

doi:10.13305/j.cnki.jts.2019.06.003

Journal of Tea Science >

2019 , Vol. 39 >Issue 6: 641 - 651

DOI: https://doi.org/10.13305/j.cnki.jts.2019.06.003

Protective Effects of Fu Brick Tea Extracts on Inflammatory Bowel Disease Induced by Dextran Sulfate Sodium in Mice

HU Ankai ,
YAO Liyun ,
ZHAO Yueling ,
LIU Chang ,
WANG Yuefei ,
XU Ping

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1. Department of dairyengineering, Northeast Agricultural University, Haerbin 150030, China;
2. Tea Research Institute, Zhejiang Univerisity, Hangzhou 310058, China

Received date: 2019-07-19

Revised date: 2019-08-25

Online published: 2019-12-24

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Abstract

Fu brick tea is a special dark tea in China. In the present work, three extracts, including Fu brick tea water extract (FWE), Fu brick tea ethanol soluble fraction (FES) and Fu brick tea ethanol precipitation fraction(FEP), were prepared and used to further explore their protective effects on inflammatory bowel disease in mice. Researches show that all the Fu brick tea extracts could alleviate the intestinal structure damage of IBD mice. Moreover, the extracts increased the activities of SOD, CAT and the levels of GSH and reduced the levels of IL-6, IL-1β, TNF-α in serum and colon tissue supernatant of mice. Furthermore, the protein level of NF-κB p65 in the colon tissues in the FWE group was decreased compared to the model group. The protein level of IκBα was increased in the FWE group and FES group. Levels of Nrf2 and HO-1 were also increased in the FWE and FES groups. In conclusion, Fu brick tea extracts had a protective effect on IBD mice induced by DSS.

Key words： Fu brick tea; inflammatory bowel disease; inflammation; oxidative stress

Cite this article

HU Ankai , YAO Liyun , ZHAO Yueling , LIU Chang , WANG Yuefei , XU Ping . Protective Effects of Fu Brick Tea Extracts on Inflammatory Bowel Disease Induced by Dextran Sulfate Sodium in Mice[J]. Journal of Tea Science, 2019 , 39(6) : 641 -651 . DOI: 10.13305/j.cnki.jts.2019.06.003

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