[1] MOKDAD A H, FORD E S, BOWMAN B A, et al.Prevalence of obesity, diabetes, and obesity-related health risk factors[J]. Jama, 2003, 289(1): 76-79.
[2] FINUCANE M M, STEVENS G A, COWAN M J, et al.National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants[J]. The Lancet, 2011, 377(9765): 557-567.
[3] MOON H-S, LEE H-G, CHOI Y-J, et al.Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity[J]. Chemico-biological Interactions, 2007, 167(2): 85-98.
[4] FUJITA H, YAMAGAMI T.Efficacy and safety of Chinese black tea (Pu-erh) extract in healthy and hypercholesterolemic subjects[J]. Annals of Nutrition and Metabolism, 2008, 53(1): 33-42.
[5] HOU Y, SHAO W, XIAO R, et al.Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model[J]. Experimental Gerontology, 2009, 44(6): 434-439.
[6] FUJITA H, YAMAGAMI T.Antihypercholesterolemic effect of Chinese black tea extract in human subjects with borderline hypercholesterolemia[J]. Nutrition Research, 2008, 28(7): 450-456.
[7] CAO Z H, GU D H, LIN Q Y, et al.Effect of Pu-erh tea on body fat and lipid profiles in rats with diet-induced obesity[J]. Phytotherapy Research, 2011, 25(2): 234-238.
[8] WOLFRAM S, WANG Y, THIELECKE F.Anti-obesity effects of green tea: from bedside to bench[J]. Molecular Nutrition & Food Research, 2006, 50(2): 176-187.
[9] HURSEL R, VIECHTBAUER W, WESTERTERP-PLANTENGA M.The effects of green tea on weight loss and weight maintenance: a meta-analysis[J]. International Journal of Obesity, 2009, 33(9): 956-961.
[10] KOVACS E M, LEJEUNE M P, NIJS I, et al.Effects of green tea on weight maintenance after body-weight loss[J]. British Journal of Nutrition, 2004, 91(3): 431-437.
[11] NAGAO T, HASE T, TOKIMITSU I.A green tea extract high in catechins reduces body fat and cardiovascular risks in humans[J]. Obesity, 2007, 15(6): 1473-1483.
[12] RAINS T M, AGARWAL S, MAKI K C.Antiobesity effects of green tea catechins: a mechanistic review[J]. The Journal of Nutritional Biochemistry, 2011, 22(1): 1-7.
[13] KHAN N, MUKHTAR H.Tea polyphenols for health promotion[J]. Life Sciences, 2007, 81(7): 519-533.
[14] ASHIDA H, FURUYASHIKI T, NAGAYASU H, et al.Anti-obesity actions of green tea: possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis-related transcription factors[J]. Biofactors, 2004, 22(1/2/3/4): 135-140.
[15] SHIMAMURA Y, MIYUKI Y, SAKAKIBARA H, et al.Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules[J]. Bioscience, Biotechnology, and Biochemistry, 2013, 77(7): 1455-1460.
[16] DING Y, ZOU X, JIANG X, et al.Pu-erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in Caenorhaditis elegans[J]. PloS One, 2015, 10(2): e0113815. Doi:10.1371/journal.pone.0113815.
[17] PENG Y, XIONG Z, LI J, et al.Water extract of the fungi from Fuzhuan brick tea improves the beneficial function on inhibiting fat deposition[J]. International Journal of Food Sciences and Nutrition, 2014, 65(5): 610-614.
[18] HEBER D, ZHANG Y, YANG J, et al.Green tea, black tea, and oolong tea polyphenols reduce visceral fat and inflammation in mice fed high-fat, high-sucrose obesogenic diets[J]. The Journal of Nutrition, 2014, 144(9): 1385-1393.
[19] EGAWA T, HAMADA T, MA X, et al.Caffeine activates preferentially α1-isoform of 5′AMP‐activated protein kinase in rat skeletal muscle[J]. Acta Physiologica, 2011, 201(2): 227-238.
[20] SHRESTHA S, EHLERS S J, LEE J-Y, et al.Dietary green tea extract lowers plasma and hepatic triglycerides and decreases the expression of sterol regulatory element-binding protein-1c mRNA and its responsive genes in fructose-fed, ovariectomized rats[J]. The Journal of Nutrition, 2009, 139(4): 640-645.
[21] COLLINS Q F, LIU H-Y, PI J, et al.Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5’-AMP-activated protein kinase[J]. Journal of Biological Chemistry, 2007, 282(41): 30143-30149.
[22] YANG C S, ZHANG J, ZHANG L, et al.Mechanisms of body weight reduction and metabolic syndrome alleviation by tea[J]. Molecular Nutrition & Food Research, 2016, 60(1): 160-174.
[23] LEE L S, CHOI J H, SUNG M J, et al.Green tea changes serum and liver metabolomic profiles in mice with high-fat diet-induced obesity[J]. Molecular Nutrition & Food Research, 2015, 59(4): 784-794.
[24] MURASE T, HARAMIZU S, SHIMOTOYODOME A, et al.Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming[J]. International Journal of Obesity, 2006, 30(3): 561-568.
[25] SHINICHI MEGURO T H, TADASHI HASE. Body fat accumulation in zebrafish is induced by a diet rich in fat and reduced by supplementation with green tea extract[J]. PloS One, 2015, 10(3): e0120142. Doi:10.1371/journal.pone.0120142.
[26] CUNHA C A, LIRA F S, ROSA NETO J C, et al. Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet[J]. Mediators of Inflammation, 2013 (6778): 635470. Doi:org/10.1155/2013/635470.
[27] SANTAMARINA A B, OLIVEIRA J L, SILVA F P, et al.Green tea extract rich in epigallocatechin-3-gallate prevents fatty liver by AMPK activation via LKB1 in mice fed a high-fat diet[J]. PloS One, 2015, 10(11): e0141227. Doi:10.1371/journal.pone.0141227.
[28] YANG X, YIN L, LI T, et al.Green tea extracts reduce adipogenesis by decreasing expression of transcription factors C/EBPα and PPARγ[J]. International Journal of Clinical and Experimental Medicine, 2014, 7(12): 4906-4914.
[29] TIAN C, YE X, ZHANG R, et al.Green tea polyphenols reduced fat deposits in high fat-fed rats via erk1/2-PPARγ-adiponectin pathway[J]. PloS One, 2013, 8(1): e53796. Doi:10.1371/journal.pone.0053796.
[30] JANSSENS P L, HURSEL R, WESTERTERP-PLANTENGA M S. Long-term green tea extract supplementation does not affect fat absorption, resting energy expenditure, and body composition in adults[J]. The Journal of Nutrition, 2015, 145(5): 864-870.
[31] HUANG J, WANG Y, XIE Z, et al.The anti-obesity effects of green tea in human intervention and basic molecular studies[J]. European Journal of Clinical Nutrition, 2014, 68(10): 1075-1087.
[32] PAN MH, LAI CS, WANG H, et al.Black tea in chemo-prevention of cancer and other human diseases[J]. Food Science and Human Wellness, 2013, 2(1): 12-21.
[33] HUNG M W WL. Chemistry and health beneficial effects of oolong tea and theasinensins[J]. Food Science and Human Wellness, 2015, 4(4): 133-146.
[34] KOO S I, NOH S K.Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect[J]. The Journal of Nutritional Biochemistry, 2007, 18(3): 179-183.
[35] SHISHIKURA Y, KHOKHAR S, MURRAY B S.Effects of tea polyphenols on emulsification of olive oil in a small intestine model system[J]. Journal of Agricultural and Food Chemistry, 2006, 54(5): 1906-1913.
[36] WANG S, NOH S K, KOO S I.Epigallocatechin gallate and caffeine differentially inhibit the intestinal absorption of cholesterol and fat in ovariectomized rats[J]. The Journal of Nutrition, 2006, 136(11): 2791-2796.
[37] WANG S, NOH S K, KOO S I.Green tea catechins inhibit pancreatic phospholipase A2 and intestinal absorption of lipids in ovariectomized rats[J]. The Journal of Nutritional Biochemistry, 2006, 17(7): 492-498.
[38] NOH S K, KIM J, SEO Y, et al. Green tea (GT) extract lowers the lymphatic absorption of benzo [a] pyrene (BaP) in rats [J]. The FASEB Journal, 2008, 22(s1): 315.5-315.
[39] WOLFRAM S.Effects of green tea and EGCG on cardiovascular and metabolic health[J]. Journal of the American College of Nutrition, 2007, 26(4): 373-388.
[40] IKEDA I, YAMAHIRA T, KATO M, et al.Black tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats[J]. Journal of Agricultural and Food Chemistry, 2010, 58(15): 8591-8595.
[41] GROVE K A, SAE-TAN S, KENNETT M J, et al.(-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice[J]. Obesity, 2012, 20(11): 2311-2313.
[42] SEO D-B, JEONG H W, CHO D, et al.Fermented green tea extract alleviates obesity and related complications and alters gut microbiota composition in diet-induced obese mice[J]. Journal of Medicinal Food, 2015, 18(5): 549-556.
[43] SALWAY J G.Metabolism at a glance[M]. Wiley-Blackwell, 2016: 50-82.
[44] ASHRAFI K.Obesity and the regulation of fat metabolism[M]. WormBook, 2007: 1-20. Doi:10.1895/wormbook.1.7.1.
[45] KENNEDY L M, PHAM S C, GRISHOK A.Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1[J]. Cell Reports, 2013, 4(5): 996-1009.
[46] SRINIVASAN S.Regulation of body fat in Caenorhabditis elegans[J]. Annual Review of Physiology, 2015, 77(1): 400-408.
[47] 张进. SREBP小分子调节剂的发现及其作用机制研究 [D]. 上海:华东师范大学, 2014.
[48] WATSON R T, KANZAKI M, PESSIN J E.Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes[J]. Endocrine reviews, 2004, 25(2): 177-204.
[49] AZZOUT-MARNICHE D, BÉCARD D, GUICHARD C, et al. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes[J]. Biochemical Journal, 2000, 350(2): 389-393.
[50] LEE D, JEONG D-E, SON H G, et al.SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat[J]. Genes & Development, 2015, 29(23): 2490-2503.
[51] TAUBERT S, VAN GILST M R, HANSEN M, et al. A mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and-independent pathways in C elegans[J]. Genes & Development, 2006, 20(9): 1137-1149.
[52] VENABLES M C, HULSTON C J, COX H R, et al.Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans[J]. The American Journal of Clinical Nutrition, 2008, 87(3): 778-784.
[53] YANG F, VOUGHT B W, SATTERLEE J S, et al.An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis[J]. Nature, 2006, 442(7103): 700-704.
[54] ASHRAFI K.Mapping out starvation responses[J]. Cell Metabolism, 2006, 3(4): 235-236.
[55] FERRE P, FOUFELLE F.SREBP-1c transcription factor and lipid homeostasis: clinical perspective[J]. Hormone Research in Paediatrics, 2007, 68(2): 72-82.
[56] S HLE J, KNOTT A, HOLTZMANN U, et al. White tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes[J]. Nutrition & Metabolism, 2009, 6(1): 20. Doi:10.1186/1743-7075-6-20.
[57] GREGOIRE F M.Adipocyte differentiation: from fibroblast to endocrine cell[J]. Experimental Biology and Medicine, 2001, 226(11): 997-1002.
[58] LIN J K, LIN-SHIAU S Y. Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols[J]. Molecular Nutrition & Food Research, 2006, 50(2): 211-217.
[59] KAO Y H, CHANG H H, LEE M J, et al.Tea, obesity, and diabetes[J]. Molecular Nutrition & Food Research, 2006, 50(2): 188-210.
[60] WOLFRAM S, RAEDERSTORFF D, PRELLER M, et al.Epigallocatechin gallate supplementation alleviates diabetes in rodents[J]. The Journal of Nutrition, 2006, 136(10): 2512-2518.
[61] WOLFRAM S, RAEDERSTORFF D, WANG Y, et al.TEAVIGOTM (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass[J]. Annals of Nutrition and Metabolism, 2005, 49(1): 54-63.
[62] CHEN N, BEZZINA R, HINCH E, et al.Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet[J]. Nutrition Research, 2009, 29(11): 784-793.
[63] BASCIANO H, FEDERICO L, ADELI K.Fructose, insulin resistance, and metabolic dyslipidemia[J]. Nutrition & Metabolism, 2005, 2(1): 5. Doi:10.1186/1743-7075-2-5.
[64] RUTLEDGE A C, ADELI K.Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms[J]. Nutrition Reviews, 2007, 65(suppl 1): S13-S23.
[65] 吕海鹏, 谷记平, 林智, 等. 普洱茶的化学成分及生物活性研究进展[J]. 茶叶科学, 2007, 27(1): 8-18.
[66] YANG D-J, HWANG L S.Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea[J]. Journal of Chromatography A, 2006, 1119(1): 277-284.
[67] 陈智雄, 齐桂年, 邹瑶, 等. 黑茶调节脂质代谢的物质基础及机理研究进展[J]. 茶叶科学, 2013, 33(3): 242-252.
[68] KUHN D J, BURNS A C, KAZI A, et al.Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2004, 1682(1): 1-10.
[69] KAUL D, SIKAND K, SHUKLA A.Effect of green tea polyphenols on the genes with atherosclerotic potential[J]. Phytotherapy Research, 2004, 18(2): 177-179.
[70] HARDIE D G.AMPK: positive and negative regulation, and its role in whole-body energy homeostasis[J]. Current Opinion in Cell Biology, 2015, 33: 1-7.
[71] XIAO B, SANDERS M J, UNDERWOOD E, et al.Structure of mammalian AMPK and its regulation by ADP[J]. Nature, 2011, 472(7342): 230-233.
[72] ZHOU J, FARAH B L, SINHA R A, et al.Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance[J]. PloS One, 2014, 9(1): e87161. Doi:10.1371/journal.pone.0087161.
[73] WAY T-D, LIN H-Y, KUO D-H, et al.Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells[J]. Journal of Agricultural and Food Chemistry, 2009, 57(12): 5257-5264.
[74] HUANG H-C, LIN J-K.Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet[J]. Food & Function, 2012, 3(2): 170-177.
[75] LONG Y C, ZIERATH J R.AMP-activated protein kinase signaling in metabolic regulation[J]. The Journal of Clinical Investigation, 2006, 116(7): 1776-1783.
[76] HARDIE D G, ROSS F A, HAWLEY S A.AMPK: a nutrient and energy sensor that maintains energy homeostasis[J]. Nature Reviews Molecular Cell Biology, 2012, 13(4): 251-262.
[77] 傅冬和, 刘仲华, 黄建安, 等. 茯砖茶降脂功能成分研究[J]. 茶叶科学, 2012, 32(3): 217-223.
[78] WANG S, MOUSTAID-MOUSSA N, CHEN L, et al.Novel insights of dietary polyphenols and obesity[J]. The Journal of Nutritional Biochemistry, 2014, 25(1): 1-18.
[79] CAO H, HININGER-FAVIER I, KELLY M A, et al.Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet[J]. Journal of Agricultural and Food Chemistry, 2007, 55(15): 6372-6378.
[80] WATTS J L.Genetic dissection of polyunsaturated fatty acid synthesis in caenorhabditis elegans[C]. Proceedings of the National Academy of Sciences, 2002, 99(9): 5854-5859.
[81] KNIAZEVA M, CRAWFORD Q T, SEIBER M, et al.Monomethyl branched-chain fatty acids play an essential role in caenorhabditis elegans development[J]. PLoS Biology, 2004, 2(9): e257.
[82] HODSON L, FIELDING B A.Stearoyl-CoA desaturase: rogue or innocent bystander?[J]. Progress in Lipid Research, 2013, 52(1): 15-42.
[83] NTAMBI J M, MIYAZAKI M.Regulation of stearoyl-CoA desaturases and role in metabolism[J]. Progress in Lipid Research, 2004, 43(2): 91-104.
[84] JEON T-I, OSBORNE T F.SREBPs: metabolic integrators in physiology and metabolism[J]. Trends in Endocrinology & Metabolism, 2012, 23(2): 65-72.
[85] BROCK T J, WATTS J L.Fatty acid desaturation and the regulation of adiposity in caenorhabditis elegans[J]. Genetics, 2007, 176(2): 865-875.
[86] NTAMBI J M, MIYAZAKI M, STOEHR J P, et al.Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity[C]. Proceedings of the National Academy of Sciences, 2002, 99(17): 11482-11486.
[87] BROCK T J, WATTS J L.Genetic regulation of unsaturated fatty acid composition in C. elegans[J]. PLoS Genetics, 2006, 2(7): e108. Doi:10.1371/journal.pgen.0020108.
[88] VAN GILST M R, HADJIVASSILIOU H, JOLLY A, et al. Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans[J]. PLoS Biol, 2005, 3(2): e53. Doi:10.1371/journal.pbio.0030053.
[89] LIANG B, FERGUSON K, KADYK L, et al.The role of nuclear receptor NHR-64 in fat storage regulation in caenorhabditis elegans[J]. PloS One, 2010, 5(3): e9869. Doi:10.1371/journal.pone.0009869.