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Journal of Tea Science ›› 2010, Vol. 30 ›› Issue (1): 1-8.doi: 10.13305/j.cnki.jts.2010.01.001

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Study on Inhibiting Effects of Tea Catechins on the Formation of Age Pigment Fluorescence Products

CAI Shu-xian1, LIU Zhong-hua1,2,*, HUANG Jian-an1, LUO Guo-an2, YU Xing-long3, DONG Xin-rong1, YANG Zhi-hui1, YE Fei1   

  1. 1. Key Laboratory of Ministry of Education for Tea Science, Hunan Agricultural University, Changsha 410128, China;
    2. Department of Chemistry of Tsinghua University and Key Laboratory of Biological Organic Phosphorus and Chemical Biology of Ministry of Education, Beijing 100084, China;
    3. College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
  • Received:2009-11-02 Revised:2009-12-14 Published:2019-09-10

Abstract: Malondialdehyde (MDA) is one of the active carbonyl compounds existing in human body, which can react with protein to form age pigment fluorescence products (APFs) by carbonyl-ammonia cross linking reaction. The purpose of this study is to determine whether tea catechins can inhibit the formation of the age pigment fluorescence products induced by MDA-modified human serum albumin (HSA). Results showed that tea catechins, especially the gallated-catechin, could inhibit the formation of APFs. The structure-activity relationship studies suggested that the inhibiting effects of tea catechins on the formation of APFs were correlated with their nucleophilicity, besides their trapping MDA directly. This research indicated that inhibiting carbonyl-ammonia cross linking reaction may be one of the mechanisms of tea catechins preventing and curing diseases resulting from carbonyl stress reaction.

Key words: tea catechins, age pigment fluorescence products (APFs), carbonyl stress, amino-carbonyl cross-linking products

CLC Number: