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Journal of Tea Science ›› 2003, Vol. 23 ›› Issue (2): 119-123.doi: 10.13305/j.cnki.jts.2003.02.007

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Effects of Tea Catechins on Lead-induced Lipid Peroxidation Damage in HepG2 Cells and Tea Polyphenol on the Content of Lead in Lead-exposed Mice

PIAO Zai-ri1, Wang Yue-fei1, YANG Xian-qiang1, CHEN Liu-ji1, YANG Yong1, ZHAO Bao-lu2, JIAO Hong-li2, ZHOU Dang-yi3   

  1. 1.Department of Tea Science, Zhejiang University, Hangzhou,310029, China;
    2. Institute of Biophysics, Academia Sinica1, Beijing 100101, China;
    3. Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
  • Received:2002-11-19 Revised:2003-05-15 Online:2003-11-25 Published:2019-09-16

Abstract: The effects of tea catechins on lead-induced lipid peroxidation damage in HepG2 cells and tea polyhenol on the content of lead in lead-exposed mice were investigated.HepG2 cell viability was determined using the MTT method,lipid peroxidation was assayed by detetmining the production rate of thibarbiturie acid reactive substance(TBARS)which was expressed as malondialdehyde(MDA)equivalents.The content of lead in lead-exposed mice was determined using hydride atomic fluorescence spectroscopic method. Results showed that tea catechins had protective effects on lead-exposed HepG2 cell viability and inhibitory effects on TBARS formation in HepG2 cells.All the indices of the mice in the exposed groups were significantly higher than those in the control.Tea polyphenol was able to accelerate the removal of lead from liver,but the same effects were not found in blood、kidney, brain and thigbones.

Key words: Tea science, Tea catechins, Tea polyphenol, Lead exposure, Lipid preoxidation, Removal of lead

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