关键词: 普洱茶提取物, 绿茶提取物, KKAy小鼠, 糖尿病大鼠, 降糖功效

Abstract: This study mainly researched the hypoglycemic effect of green tea extract and Pu'er tea extract by two animal models. C57BL/6J mice were selected as control group, KKAy mice were randomly grouped. They were all orally given Pu'er tea extract and green tea extract for 4 weeks. At last we selected the fasting blood glucose and AUC as objects of observation, compare the effect of green tea extract and Pu'er tea extract. We selected these two kinds of tea extract which were given orally to rats that were caused diabetic model by STZ. The results showed that both Pu'er tea extract and green tea extract could reduce the content of fasting blood glucose, the AUC at two model experiments. But the difference was that Pu'er tea extract was superior to green tea extract in fasting blood glucose and impaired AUC. At the same time Pu'er tea extract could significantly decrease the level of insulin resistance than that of green tea extract. But in decreasing the levels of fasting serum insulin, green tea extract slowed no evident difference in comparing with the model group. In the comparing of two tea extracts on diabetes target enzyme such as aldose reductase and PTP1B inhibition in vitro, the results showed that Pu'er tea extracts strongly inhibited PTP1B activity, the inhibition rate was 88.0%, green tea extract had no inhibitory effects on the enzyme. So after comprehensive evaluation the hypoglycemic effect of Pu'er tea’s extracts was better than that of green tea extracts.

Key words: Pu'er tea extract, green tea extract, KKAy mice, diabetes rat, hypoglycemic effect